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Verfasst von:Bartenschlager, Ralf [VerfasserIn]   i
 Cornberg, Markus [VerfasserIn]   i
 Pietschmann, Thomas [VerfasserIn]   i
Titel:Maßgeschneiderte Therapie der Virushepatitis der Gegenwart und Zukunft
Titelzusatz:Hepatitis B, C, Delta und E
Verf.angabe:R. Bartenschlager, M. Cornberg, T. Pietschmann
E-Jahr:2017
Jahr:19. Juni 2017
Umfang:9 S.
Fussnoten:Gesehen am 01.10.2018
Titel Quelle:Enthalten in: Der Internist
Ort Quelle:Berlin : Springer, 1996
Jahr Quelle:2017
Band/Heft Quelle:58(2017), 7, Seite 666-674
ISSN Quelle:1432-1289
Abstract:Precision medicine is also possible for infectious diseases as shown for the treatment of chronic viral hepatitis, especially if different options are available. In hepatitis B virus (HBV) infection, treatment indication as well as the choice of treatment and the decisions to stop treatment are based on viral markers and alanine aminotransferase (ALT) level. Future therapies for HBV infection aiming for functional cure or even virus elimination may be even more personalized and have to take into account the immune status of a given patient. Such treatment modalities might also increase the chance for successful treatment of chronic hepatitis delta where treatment options are still very limited. Some new therapeutic concepts targeting host receptors or host enzymes are promising, but may require individualized approaches. Chronic hepatitis C is a good example for precision medicine based on viral and host factors. However, the main reason for individualized direct-acting antiviral (DAA) treatment is to save costs. As DAAs are effective in more than 95% of patients, elimination of HCV seems to be possible at the level of a given country or even on a global scale. However, owing to high reinfection rates in high-risk groups and limited availability of antiviral therapy in many high endemic countries, it must still be decided whether an HCV vaccine or pre-exposure prophylaxis is required to achieve this goal. Hepatitis E is an emerging topic as this is the most frequent acute hepatitis virus infection. It can result in a chronic infection in immunosuppressed individuals. Treatment options are still limited and individualized management is based on tailoring immunosuppressive therapy and therapy with ribavirin. Thus, personalized therapy of hepatitis E virus infection is still limited.
DOI:doi:10.1007/s00108-017-0262-8
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1007/s00108-017-0262-8
 Volltext: https://doi.org/10.1007/s00108-017-0262-8
 DOI: https://doi.org/10.1007/s00108-017-0262-8
Datenträger:Online-Ressource
Sprache:ger
Sach-SW:Antiviral agents
 direct-acting
 Direkt antiviral wirkende Medikamente
 hepatitis C
 Hepatitis-C-Impfung
 Peginterferon alfa
 Pegyliertes Interferon-alfa
 Ribavirin
 Sofosbuvir
 Vaccination
K10plus-PPN:158145340X
Verknüpfungen:→ Zeitschrift

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