Evidence of microglial activation following exposure to serum from first-onset drug-naïve schizophrenia patients

• Verfasst von: Rees, Geertje Frederique van [VerfasserIn]
• Verfasst von: Leweke, F. Markus [VerfasserIn]
• Titel: Evidence of microglial activation following exposure to serum from first-onset drug-naïve schizophrenia patients
• Verf.angabe: Geertje Frederique van Rees, Santiago Guillermo Lago, David Alan Cox, Jakub Tomasik, Nitin Rustogi, Karin Weigelt, Sureyya Ozcan, Jason Cooper, Hemmo Drexhage, F. Markus Leweke, Sabine Bahn
• Jahr: 2018
• Jahr des Originals: 2017
• Umfang: 10 S.
• Fussnoten: Available online 4 October 2017 ; Gesehen am 01.10.2018
• Titel Quelle: Enthalten in: Brain, behavior and immunity
• Ort Quelle: Orlando, Fla. [u.a.] : Elsevier, 1987
• Jahr Quelle: 2018
• Band/Heft Quelle: 67(2018), Seite 364-373
• ISSN Quelle: 1090-2139
• DOI: doi:10.1016/j.bbi.2017.10.003
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Drug target
• Sach-SW: Inflammation
• Sach-SW: Microglia
• Sach-SW: mTORC1
• Sach-SW: Phosphoflow
• Sach-SW: Psychiatric disorders
• Sach-SW: Stat3
• K10plus-PPN: 1581456689

Abstract

Abnormal activation of brain microglial cells is widely implicated in the pathogenesis of schizophrenia. Previously the pathophysiology of microglial activation was considered to be intrinsic to the central nervous system. We hypothesised that due to their perivascular localization, microglia can also be activated by factors present in circulating blood. Through application of high-content functional screening, we show that peripheral blood serum from first-onset drug-naïve schizophrenia patients is sufficient to provoke microglial cell signalling network responses in vitro which are indicative of proinflammatory activation. We further explore the composition of the serum for the presence of analytes, with the potential to activate microglia, and the utility of the resultant microglial cellular phenotype for novel drug discovery.