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Status: Bibliographieeintrag

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Verfasst von:Costello, Joseph [VerfasserIn]   i
 Islinger, Markus [VerfasserIn]   i
Titel:Predicting the targeting of tail-anchored proteins to subcellular compartments in mammalian cells
Verf.angabe:Joseph L. Costello, Inês G. Castro, Fátima Camões, Tina A. Schrader, Doug McNeall, Jing Yang, Evdokia-Anastasia Giannopoulou, Sílvia Gomes, Vivian Pogenberg, Nina A. Bonekamp, Daniela Ribeiro, Matthias Wilmanns, Gregory Jedd, Markus Islinger and Michael Schrader
Jahr:2017
Umfang:13 S.
Fussnoten:Gesehen am 01.10.2018
Titel Quelle:Enthalten in: Journal of cell science
Ort Quelle:Cambridge : Company of Biologists Limited, 1853
Jahr Quelle:2017
Band/Heft Quelle:130(2017), 9, Seite 1675-1687
ISSN Quelle:1477-9137
Abstract:Skip to Next Section Tail-anchored (TA) proteins contain a single transmembrane domain (TMD) at the C-terminus that anchors them to the membranes of organelles where they mediate critical cellular processes. Accordingly, mutations in genes encoding TA proteins have been identified in a number of severe inherited disorders. Despite the importance of correctly targeting a TA protein to its appropriate membrane, the mechanisms and signals involved are not fully understood. In this study, we identify additional peroxisomal TA proteins, discover more proteins that are present on multiple organelles, and reveal that a combination of TMD hydrophobicity and tail charge determines targeting to distinct organelle locations in mammals. Specifically, an increase in tail charge can override a hydrophobic TMD signal and re-direct a protein from the ER to peroxisomes or mitochondria and vice versa. We show that subtle changes in those parameters can shift TA proteins between organelles, explaining why peroxisomes and mitochondria have many of the same TA proteins. This enabled us to associate characteristic physicochemical parameters in TA proteins with particular organelle groups. Using this classification allowed successful prediction of the location of uncharacterized TA proteins for the first time.
DOI:doi:10.1242/jcs.200204
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: http://dx.doi.org/10.1242/jcs.200204
 kostenfrei: Volltext: http://jcs.biologists.org/content/130/9/1675
 DOI: https://doi.org/10.1242/jcs.200204
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1581459971
Verknüpfungen:→ Zeitschrift

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