Value and feasibility of LLETZ procedures for pregnant women with suspected high-grade squamous intraepithelial lesions and microinvasive cervical cancer

• Verfasst von: Schäfer, Kristina [VerfasserIn]
• Verfasst von: Peters, Dorothee Julia [VerfasserIn]
• Verfasst von: Aulmann, Sebastian [VerfasserIn]
• Verfasst von: Sohn, Christof [VerfasserIn]
• Verfasst von: Eichbaum, Michael H. R. [VerfasserIn]
• Titel: Value and feasibility of LLETZ procedures for pregnant women with suspected high-grade squamous intraepithelial lesions and microinvasive cervical cancer
• Verf.angabe: Kristina Schaefer, Dorothee Peters, Sebastian Aulmann, Christof Sohn, Michael H. R. Eichbaum
• E-Jahr: 2012
• Jahr: 29 May 2012
• Umfang: 4 S.
• Teil: volume:118
• Teil: year:2012
• Teil: number:2
• Teil: pages:141-144
• Teil: extent:4
• Fussnoten: Gesehen am 01.10.2018
• Titel Quelle: Enthalten in: International journal of gynecology & obstetrics
• Ort Quelle: Hoboken, NJ : Wiley, 1969
• Jahr Quelle: 2012
• Band/Heft Quelle: 118(2012), 2, Seite 141-144
• ISSN Quelle: 1879-3479
• DOI: doi:10.1016/j.ijgo.2012.02.019
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Cervical cancer
• Sach-SW: Cervical intraepithelial neoplasia
• Sach-SW: Conization
• Sach-SW: High-grade squamous intraepithelial lesions
• Sach-SW: Large loop excision of the transformation zone
• Sach-SW: Pregnancy
• K10plus-PPN: 1581463243

Abstract

Objective To evaluate the efficacy, safety, and feasibility of large loop excision of the transformation zone (LLETZ) procedures during pregnancy. Methods A retrospective study included 27 patients who underwent LLETZ during pregnancy for suspected high-grade squamous intraepithelial lesions (HSIL) where microinvasion could not be excluded. The study investigated intraoperative and postoperative complications, and compared preoperative and postoperative results. Questionnaires were used to obtain information about peripartum and postpartum data. Results Three (11.1%) women had invasive or microinvasive cancer, 22 (81.5%) had cervical intraepithelial neoplasia (CIN) 3, and 1 (3.7%) had CIN 2. Twenty-four were positive for high-risk human papillomavirus. All cervical cancers were classified as HSIL or CIN 3 before LLETZ. There were positive resection margins in 15 (55.6%) cases. No intraoperative complications occurred. One (3.7%) patient had a postoperative missed abortion. Major complications such as premature labor or cervical incompetence without influence on delivery occurred after LLETZ in 4 (14.8%) patients. Conclusion LLETZ during pregnancy can be performed if invasive cancer cannot be excluded by colposcopy, cytology, or biopsy. The procedure has a diagnostic intention but can also be a curative therapy in pregnancy, with low intraoperative, postoperative, and peripartum complication rates.