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Verfasst von:Acharya, Sreemukta [VerfasserIn]   i
 Erhardt, Sylvia [VerfasserIn]   i
Titel:Chromatin-associated noncoding RNAs in development and inheritance
Mitwirkende:Hartmann, Mark   i
Verf.angabe:Sreemukta Acharya, Mark Hartmann and Sylvia Erhardt
E-Jahr:2017
Jahr:25 August 2017
Umfang:22 S.
Teil:volume:8
 year:2017
 number:6
 elocationid:e1435
 extent:22
Fussnoten:Gesehen am 02.10.2018
Titel Quelle:Enthalten in: Wiley interdisciplinary reviews / RNA
Ort Quelle:Malden, MA : Wiley-Blackwell, 2010
Jahr Quelle:2017
Band/Heft Quelle:8(2017), 6, Artikel-ID e1435
ISSN Quelle:1757-7012
Abstract:Noncoding RNAs (ncRNAs) have emerged as crucial players in chromatin regulation. Their diversity allows them to partake in the regulation of numerous cellular processes across species. During development, long and short ncRNAs act in conjunction with each other where long ncRNAs (lncRNAs) are best understood in establishing appropriate gene expression patterns, while short ncRNAs (sRNAs) are known to establish constitutive heterochromatin and suppress mobile elements. Additionally, increasing evidence demonstrates roles of sRNAs in several typically lncRNA-mediated processes such as dosage compensation, indicating a complex regulatory network of noncoding RNAs. Together, various ncRNAs establish many mitotically heritable epigenetic marks during development. Additionally, they participate in mechanisms that regulate maintenance of these epigenetic marks during the lifespan of the organism. Interestingly, some epigenetic traits are transmitted to the next generation(s) via paramutations or transgenerational inheritance mediated by sRNAs. In this review, we give an overview of the various functions and regulations of ncRNAs and the mechanisms they employ in the establishment and maintenance of epigenetic marks and multi-generational transmission of epigenetic traits. WIREs RNA 2017, 8:e1435. doi: 10.1002/wrna.1435 This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs RNA in Disease and Development > RNA in Development
DOI:doi:10.1002/wrna.1435
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1002/wrna.1435
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/wrna.1435
 DOI: https://doi.org/10.1002/wrna.1435
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1581476035
Verknüpfungen:→ Zeitschrift

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