The effect of body mass index on clinical response to abatacept as a first-line biologic for rheumatoid arthritis

• Verfasst von: Mariette, Xavier [VerfasserIn]
• Verfasst von: Lorenz, Hanns-Martin [VerfasserIn]
• Titel: The effect of body mass index on clinical response to abatacept as a first-line biologic for rheumatoid arthritis
• Titelzusatz: 6-month results from the 2-year, observational, prospective ACTION study
• Verf.angabe: Xavier Mariette, Rieke Alten, Hubert G. Nüßlein, Mauro Galeazzi, Hanns-Martin Lorenz, Alain Cantagrel, Melanie Chartier, Coralie Poncet, Christiane Rauch, Manuela Le Bars
• Jahr des Originals: 2016
• Umfang: 6 S.
• Fussnoten: Available online 30 December 2016 ; Gesehen am 02.10.2018
• Titel Quelle: Enthalten in: Joint bone spine
• Jahr Quelle: 2017
• Band/Heft Quelle: 84(2017), 5, S. 571-576
• ISSN Quelle: 1778-7254
• DOI: doi:10.1016/j.jbspin.2016.10.011
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1581496451

Abstract

Objective:To assess the impact of baseline body mass index (BMI) on the efficacy and retention of intravenous abatacept at 6 months in biologic-naïve patients with rheumatoid arthritis (RA). Methods: This was a 6-month analysis of a 2-year, non-interventional, international, prospective study. Baseline characteristics, clinical response and retention rates were compared by BMI subgroup: underweight/normal, overweight and obese (<25, 25 to <30 and ≥30kg/m2, respectively). Results: BMI was reported in 643/672 (96%) patients: 264 (41%) were underweight/normal, 224 (35%) overweight and 155 (24%) obese. At baseline, the obese group had more active disease (mean [95% confidence intervals] 28-joint Disease Activity Score [C-reactive protein; derived] 4.6 [4.5, 4.7], 4.8 [4.7, 5.0] and 5.1 [4.9, 5.2] for underweight/normal, overweight and obese groups, respectively), a higher prevalence of metabolic disorders, a greater proportion of women and a lower proportion of patients with rheumatoid factor positivity. There were no significant differences in the percentages of patients achieving a good/moderate European League Against Rheumatism response by BMI group (80.7, 86.1 and 77.0% for underweight/normal, overweight and obese groups, respectively; P=0.178). Overall retention rates at 6 months did not differ across groups (89, 92 and 89% for underweight/normal, overweight and obese groups, respectively; log-rank P=0.382). After adjustment for baseline characteristics, BMI was not significantly associated with risk of discontinuation (reference BMI<25kg/m2; hazard ratio [95% confidence intervals] 0.46 [0.22, 0.99] and 0.69 [0.34, 1.41] for overweight and obese patients, respectively). Conclusion: BMI does not impact abatacept clinical response or retention in biologic-naïve patients with RA.