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| Verfasst von: | Barre, Max [VerfasserIn]  |
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| | Behnes, Michael [VerfasserIn] |
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| | Hamed, Sonja [VerfasserIn] |
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| | Pauly, Dominic [VerfasserIn] |
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| | Lepiorz, Dominic [VerfasserIn] |
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| | Lang, Siegfried [VerfasserIn] |
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| | Akın, Ibrahim [VerfasserIn] |
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| | Borggrefe, Martin [VerfasserIn] |
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| | Hoffmann, Ursula [VerfasserIn] |
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| Titel: | Revisiting the prognostic value of monocyte chemotactic protein 1 and interleukin-6 in the sepsis-3 era |
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| Verf.angabe: | Max Barre, Michael Behnes, Sonja Hamed, Dominic Pauly, Dominic Lepiorz, Siegfried Lang, Ibrahim Akin, Martin Borggrefe, Thomas Bertsch, Ursula Hoffmann |
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| Jahr: | 2018 |
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| Jahr des Originals: | 2017 |
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| Umfang: | 8 S. |
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| Fussnoten: | Available online 15 August 2017 ; Gesehen am 02.10.2018 |
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| Titel Quelle: | Enthalten in: Journal of critical care |
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| Ort Quelle: | [Amsterdam] : Elsevier, 1986 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 43(2018), Seite 21-28 |
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| ISSN Quelle: | 1557-8615 |
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| Abstract: | Background: Monocyte Chemotactic Protein 1 (MCP1) and latest sepsis-3 criteria are poorly represented within studies evaluating biomarkers in sepsis. Therefore, this study evaluates the prognostic value of MCP-1 compared to interleukin-6 (IL-6) in patients with sepsis and septic shock according to sepsis-3 criteria. Methods: 136 patients with sepsis or septic shock were included within 24h of intensive care unit (ICU) admission. MCP-1, IL-6, procalcitonin (PCT), C-reactive protein (CRP) and white blood cells (WBC) were measured on days 1, 3 and 8. All-cause mortality was followed up at 30days and 6months. Results: Both MCP-1 and IL-6 levels revealed valuable prognostic discrimination of 30-day and 6-months all-cause mortality on day 1 and 3 (MCP-1: range of AUCs 0.62-0.65, p<0.039; IL-6: range of AUCs 0.65-0.70, p<0.021) compared to PCT, CRP, SOFA and APACHE II score. MCP-1 levels within the 4th quartile revealed the highest mortality at 30days and 6months compared to patients with lower levels (range of hazard ratio (HR)=2.1-3.3, p<0.041). The prognostic value of MCP-1 sustained in multivariate regression models and was comparable to that of IL-6. Conclusion: Both MCP-1 and IL-6 revealed prognostic value for short- and mid-term all-cause mortality in patients with sepsis and septic shock according to latest sepsis-3 definitions. |
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| DOI: | doi:10.1016/j.jcrc.2017.08.024 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.jcrc.2017.08.024 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S088394411730847X |
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| | DOI: https://doi.org/10.1016/j.jcrc.2017.08.024 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Biomarker |
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| | Intensive care unit |
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| | MCP-1 |
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| | Prognosis |
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| | Sepsis |
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| | Septic shock |
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| K10plus-PPN: | 1581503938 |
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| Verknüpfungen: | → Zeitschrift |
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Revisiting the prognostic value of monocyte chemotactic protein 1 and interleukin-6 in the sepsis-3 era / Barre, Max [VerfasserIn]; 2018 (Online-Ressource)
