| Online-Ressource |
Verfasst von: | Barre, Max [VerfasserIn]  |
| Behnes, Michael [VerfasserIn]  |
| Hamed, Sonja [VerfasserIn]  |
| Pauly, Dominic [VerfasserIn]  |
| Lepiorz, Dominic [VerfasserIn]  |
| Lang, Siegfried [VerfasserIn]  |
| Akın, Ibrahim [VerfasserIn]  |
| Borggrefe, Martin [VerfasserIn]  |
| Hoffmann, Ursula [VerfasserIn]  |
Titel: | Revisiting the prognostic value of monocyte chemotactic protein 1 and interleukin-6 in the sepsis-3 era |
Verf.angabe: | Max Barre, Michael Behnes, Sonja Hamed, Dominic Pauly, Dominic Lepiorz, Siegfried Lang, Ibrahim Akin, Martin Borggrefe, Thomas Bertsch, Ursula Hoffmann |
Jahr: | 2018 |
Jahr des Originals: | 2017 |
Umfang: | 8 S. |
Fussnoten: | Available online 15 August 2017 ; Gesehen am 02.10.2018 |
Titel Quelle: | Enthalten in: Journal of critical care |
Ort Quelle: | [Amsterdam] : Elsevier, 1986 |
Jahr Quelle: | 2018 |
Band/Heft Quelle: | 43(2018), Seite 21-28 |
ISSN Quelle: | 1557-8615 |
Abstract: | Background: Monocyte Chemotactic Protein 1 (MCP1) and latest sepsis-3 criteria are poorly represented within studies evaluating biomarkers in sepsis. Therefore, this study evaluates the prognostic value of MCP-1 compared to interleukin-6 (IL-6) in patients with sepsis and septic shock according to sepsis-3 criteria. Methods: 136 patients with sepsis or septic shock were included within 24h of intensive care unit (ICU) admission. MCP-1, IL-6, procalcitonin (PCT), C-reactive protein (CRP) and white blood cells (WBC) were measured on days 1, 3 and 8. All-cause mortality was followed up at 30days and 6months. Results: Both MCP-1 and IL-6 levels revealed valuable prognostic discrimination of 30-day and 6-months all-cause mortality on day 1 and 3 (MCP-1: range of AUCs 0.62-0.65, p<0.039; IL-6: range of AUCs 0.65-0.70, p<0.021) compared to PCT, CRP, SOFA and APACHE II score. MCP-1 levels within the 4th quartile revealed the highest mortality at 30days and 6months compared to patients with lower levels (range of hazard ratio (HR)=2.1-3.3, p<0.041). The prognostic value of MCP-1 sustained in multivariate regression models and was comparable to that of IL-6. Conclusion: Both MCP-1 and IL-6 revealed prognostic value for short- and mid-term all-cause mortality in patients with sepsis and septic shock according to latest sepsis-3 definitions. |
DOI: | doi:10.1016/j.jcrc.2017.08.024 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.jcrc.2017.08.024 |
| Volltext: http://www.sciencedirect.com/science/article/pii/S088394411730847X |
| DOI: https://doi.org/10.1016/j.jcrc.2017.08.024 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Biomarker |
| Intensive care unit |
| MCP-1 |
| Prognosis |
| Sepsis |
| Septic shock |
K10plus-PPN: | 1581503938 |
Verknüpfungen: | → Zeitschrift |
Revisiting the prognostic value of monocyte chemotactic protein 1 and interleukin-6 in the sepsis-3 era / Barre, Max [VerfasserIn]; 2018 (Online-Ressource)