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Verfasst von:Schäfer, Betti [VerfasserIn]   i
 Wühl, Elke [VerfasserIn]   i
Titel:Educational paper: Progression in chronic kidney disease and prevention strategies
Verf.angabe:Betti Schaefer, Elke Wühl
E-Jahr:2012
Jahr:12 September 2012
Umfang:10 S.
Teil:volume:171
 year:2012
 number:11
 pages:1579-1588
 extent:10
Fussnoten:Gesehen am 02.10.2018
Titel Quelle:Enthalten in: European journal of pediatrics
Ort Quelle:Berlin : Springer Science & Business Media B.V., 1975
Jahr Quelle:2012
Band/Heft Quelle:171(2012), 11, Seite 1579-1588
ISSN Quelle:1432-1076
Abstract:Chronic kidney disease (CKD) in children is a rare but devastating condition. Once a critical amount of nephron mass has been lost, progression of CKD is irreversible and results in end-stage renal disease (ESRD) and need of renal replacement therapy. The time course of childhood CKD is highly variable. While in children suffering from congenital anomalies of the kidneys and the urinary tract, progression of CKD in general is slow, in children with acquired glomerulopathies, disease progression can be accelerated resulting in ESRD within months. However, irrespective of the underlying kidney disease, hypertension and proteinuria are independent risk factors for progression. Thus, in order to prevent progression, the primary objective of treatment should always aim for efficient control of blood pressure and reduction of urinary protein excretion. Blockade of the renin-angiotensin-aldosterone system preserves kidney function not only by lowering blood pressure, but also by reducing proteinuria and exerting additional anti-proteinuric, anti-fibrotic, and anti-inflammatory effects. Besides, intensified blood pressure control, aiming for a target blood pressure below the 50th percentile, may exert additive renoprotective effects. Additionally, other modifiable risk factors, such as anemia, metabolic acidosis, dyslipidemia, and altered bone-mineral homeostasis may also contribute to CKD progression. In conclusion, beyond strict blood pressure control and reduction of urinary protein excretion, identification and treatment of both, renal disease-related and conventional risk factors are mandatory in children with CKD in order to prevent deterioration of kidney function.
DOI:doi:10.1007/s00431-012-1814-5
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1007/s00431-012-1814-5
 Volltext: https://doi.org/10.1007/s00431-012-1814-5
 DOI: https://doi.org/10.1007/s00431-012-1814-5
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Anemia
 Bone mineral metabolism
 Children
 Chronic kidney disease
 Dyslipidemia
 Hypertension
 Inflammation
 Nutrition
 Proteinuria
 Renal disease progression
K10plus-PPN:1581504675
Verknüpfungen:→ Zeitschrift

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