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Verfasst von:Umansky, Viktor [VerfasserIn]   i
 Sevko, Alexandra [VerfasserIn]   i
Titel:Melanoma-induced immunosuppression and its neutralization
Verf.angabe:Viktor Umansky, Alexandra Sevko
Jahr:2012
Umfang:8 S.
Fussnoten:Available online 13 February 2012 ; Gesehen am 04.10.2018
Titel Quelle:Enthalten in: Seminars in cancer biology
Ort Quelle:London : Academic Press, 1995
Jahr Quelle:2012
Band/Heft Quelle:22(2012), 4, Seite 319-326
ISSN Quelle:1096-3650
Abstract:Malignant melanoma is characterized by a rapid progression, metastasis to distant organs, and resistance to chemo- and radiotherapy. Well-defined immunogenic capacities of melanoma cells should allow a successful application of different immunotherapeutic strategies. However, the overall results of immunotherapeutic clinical studies are not satisfactory. These paradoxical observations are supposed to be due to the profound immunosuppression mediated by different mechanisms dealing with alterations in tumor and surrounding stroma cells. Melanoma microenvironment has been characterized by a remarkable accumulation of highly immunosuppressive regulatory leucocytes, in particular, myeloid-derived suppressor cells (MDSCs). Their migration, retention and high activity in the tumor lesions have been demonstrated to be induced by chronic inflammatory conditions developing in the tumor microenvironment and characterized by the long-term secretion of various inflammatory mediators (cytokines, chemokines, growth factors, reactive oxygen and nitrogen species, prostaglandins etc.) leading to further cancer progression. Here, we discuss the role of chronic inflammation in the recruitment and activation of MDSCs in melanoma lesions as well as therapeutic approaches of MDSC targeting to overcome tumor immunosuppressive microenvironment induced by chronic inflammation and enhance the efficiency of melanoma immunotherapies.
DOI:doi:10.1016/j.semcancer.2012.02.003
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.semcancer.2012.02.003
 Volltext: http://www.sciencedirect.com/science/article/pii/S1044579X12000260
 DOI: https://doi.org/10.1016/j.semcancer.2012.02.003
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Chronic inflammation
 Immunosuppression
 Melanoma
 Myeloid-derived suppressor cells
 Tumor microenvironment
K10plus-PPN:1581534892
Verknüpfungen:→ Zeitschrift

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