Fibroid explants reveal a higher sensitivity against MDM2-inhibitor nutlin-3 than matching myometrium

• Verfasst von: Markowski, Dominique Nadine [VerfasserIn]
• Verfasst von: Helmke, Burkhard Maria [VerfasserIn]
• Verfasst von: Radtke, Arlo [VerfasserIn]
• Titel: Fibroid explants reveal a higher sensitivity against MDM2-inhibitor nutlin-3 than matching myometrium
• Verf.angabe: Dominique N. Markowski, Burkhard M. Helmke, Arlo Radtke, Jennifer Froeb, Gazanfer Belge, Sabine Bartnitzke, Werner Wosniok, Iris Czybulka-Jachertz, Ulrich Deichert and Jörn Bullerdiek
• E-Jahr: 2012
• Jahr: 10 January 2012
• Umfang: 11 S.
• Teil: volume:12
• Teil: year:2012
• Teil: elocationid:2
• Teil: extent:11
• Fussnoten: Gesehen am 04.10.2018
• Titel Quelle: Enthalten in: BMC women's health
• Ort Quelle: London : BioMed Central, 2001
• Jahr Quelle: 2012
• Band/Heft Quelle: 12(2012), Artikel-ID 2
• ISSN Quelle: 1472-6874
• DOI: doi:10.1186/1472-6874-12-2
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1581541813

Abstract

Spontaneous cessation of growth is a frequent finding in uterine fibroids. Increasing evidence suggests an important role of cellular senescence in this growth control. Deciphering the underlying mechanisms of growth control that can be expected not only to shed light on the biology of the tumors but also to identify novel therapeutic targets.