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Status: Bibliographieeintrag

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Verfasst von:Marmé, Frederik [VerfasserIn]   i
 Hielscher, Thomas [VerfasserIn]   i
 Fastner, Sarah [VerfasserIn]   i
 Bondong, Sandra [VerfasserIn]   i
 Ferschke, Irmgard [VerfasserIn]   i
 Rom, Joachim [VerfasserIn]   i
 Sohn, Christof [VerfasserIn]   i
 Schneeweiss, Andreas [VerfasserIn]   i
 Altevogt, Peter [VerfasserIn]   i
Titel:Fibroblast growth factor receptor 4 gene (FGFR4) 388Arg allele predicts prolonged survival and platinum sensitivity in advanced ovarian cancer
Verf.angabe:Frederik Marmé, Thomas Hielscher, Sarah Hug, Sandra Bondong, Robert Zeillinger, Dan Cacsire Castillo‐Tong, Jalid Sehouli, Ioana Braicu, Ignace Vergote, Cadron Isabella, Sven Mahner, Irmgard Ferschke, Joachim Rom, Christof Sohn, Andreas Schneeweiss, Peter Altevogt
Jahr:2012
Umfang:6 S.
Fussnoten:First published 27 October 2011 ; Gesehen am 04-10-2018
Titel Quelle:Enthalten in: International journal of cancer
Ort Quelle:Bognor Regis : Wiley-Liss, 1966
Jahr Quelle:2012
Band/Heft Quelle:131(2012), 4, Seite E586-E591
ISSN Quelle:1097-0215
Abstract:FGFR4 has been shown to play an important role in the etiology and progression of solid tumors. A single nucleotide polymorphism (SNP) within the FGFR4 gene has previously been linked to prognosis and response to chemotherapy in breast cancer and other malignancies. This study evaluates the relevance of this SNP in advanced ovarian cancer. FGFR4-genotype was analyzed in 236 patients recruited as part of the OVCAD project. Genotyping was performed on germ-line DNA using a TaqMan based genotyping assay. Results were correlated with clinicopathological variables and survival. The FGFR4 388Arg genotype was significantly associated with prolonged progression-free and overall survival (univariate: HR 0.68, p = 0.017; HR 0.49, p = 0.005; multivariate: HR 0.69, p = 0.025; HR 0.49, p = 0.006) though the positive prognostic value was restricted to patients without postoperative residual tumor. Indeed, there was a significant interaction between FGFR4 genotype and residual tumor for overall survival. Furthermore, the FGFR4 388Arg genotype significantly correlated with platinum sensitivity in the same subgroup (multivariate OR 3.81 p = 0.004). FGFR4 Arg388Gly genotype is an independent and strong context specific prognostic factor in patients with advanced ovarian cancer and could be used to predict platinum-sensitivity.
DOI:doi:10.1002/ijc.27329
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1002/ijc.27329
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.27329
 DOI: https://doi.org/10.1002/ijc.27329
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:prognosis
 FGFR4
 ovarian cancer
 OVCAD
 polymorphism
 prediction
 SNP
K10plus-PPN:1581546580
Verknüpfungen:→ Zeitschrift

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