Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in adult and pediatric burn patients

• Verfasst von: Hundeshagen, Gabriel
• Titel: Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in adult and pediatric burn patients
• Verf.angabe: Gabriel Hundeshagen, David N. Herndon, Karel D. Capek, Ludwik K. Branski, Charles D. Voigt, Elizabeth A. Killion, Janos Cambiaso-Daniel, Michaela Sljivich, Andrew De Crescenzo, Ronald P. Mlcak, Michael P. Kinsky, Celeste C. Finnerty, William B. Norbury
• E-Jahr: 2017
• Jahr: 20 December 2017
• Umfang: 10 S.
• Fussnoten: Gesehen am 04.10.2018
• Titel Quelle: Enthalten in: Critical care
• Ort Quelle: London : BioMed Central, 1997
• Jahr Quelle: 2017
• Band/Heft Quelle: 21(2017), Artikel-ID 318
• ISSN Quelle: 1466-609X
• DOI: doi:10.1186/s13054-017-1899-3
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1581554680

Abstract

Burn patients are prone to infections which often necessitate broad antibiotic coverage. Vancomycin is a common antibiotic after burn injury and is administered alone (V), or in combination with imipenem-cilastin (V/IC) or piperacillin-tazobactam (V/PT). Sparse reports indicate that the combination V/PT is associated with increased renal dysfunction. The purpose of this study was to evaluate the short-term impact of the three antibiotic administration types on renal dysfunction.