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Verfasst von:Friedrich, Kilian [VerfasserIn]   i
 Wannhoff, Andreas [VerfasserIn]   i
 Rupp, Christian [VerfasserIn]   i
 Antoni, Christoph Helmer [VerfasserIn]   i
 Stremmel, Wolfgang [VerfasserIn]   i
 Weiss, Karl Heinz [VerfasserIn]   i
 Schemmer, Peter [VerfasserIn]   i
 Gotthardt, Daniel [VerfasserIn]   i
Titel:Coffee consumption protects against progression in liver cirrhosis and increases long-term survival after liver transplantation
Verf.angabe:Kilian Friedrich, Mark Smit, Andreas Wannhoff, Christian Rupp, Sabine G. Scholl, Christoph Antoni, Matthias Dollinger, Christoph Neumann‐Haefelin, Wolfgang Stremmel, Karl Heinz Weiss, Peter Schemmer and Daniel Nils Gotthardt
E-Jahr:2016
Jahr:August 2016
Umfang:6 S.
Fussnoten:First published: 15 February 2016 ; Gesehen am 05.10.2018
Titel Quelle:Enthalten in: Journal of gastroenterology and hepatology
Ort Quelle:Oxford [u.a.] : Wiley-Blackwell, 1986
Jahr Quelle:2016
Band/Heft Quelle:31(2016), 8, Seite 1470-1475
ISSN Quelle:1440-1746
Abstract:Background Therapeutic options to treat progression of end-stage liver disease (ESLD) or improve long-term survival after liver transplantation remain scarce. We investigated the impact of coffee consumption under these conditions. Methods We recorded coffee consumption habits of 379 patients with ESLD awaiting liver transplantation and 260 patients after liver transplantation. Survival was analyzed based on coffee intake. Results One hundred ninety-five patients with ESLD consumed coffee on a daily basis, while 184 patients did not. Actuarial survival was impaired (P = 0.041) in non-coffee drinkers (40.4 ± 4.3 months, 95% confidence interval [CI]: 32.0-48.9) compared with coffee drinkers (54.9 ± 5.5 months, 95% CI: 44.0-65.7). In subgroup analysis, the survival of patients with alcoholic liver disease (ALD; P = 0.020) and primary sclerosing cholangitis (PSC; P = 0.017) was increased with coffee intake while unaffected in patients with chronic viral hepatitis (P = 0.517) or other liver disease entities (P = 0.652). Multivariate analysis showed that coffee consumption of PSC and ALD patients retained as an independent risk factor (odds ratio [OR]: 1.94; 95% CI: 1.15-3.28; P = 0.013) along with MELD score (OR: 1.13; 95% CI: 1.09-1.17; P = 0.000). Following liver transplantation, long-term survival was longer in coffee drinkers (coffee: 61.8 ± 2.0 months, 95% CI: 57.9-65.8) than non-drinkers (52.3 ± 3.5 months, 95% CI: 45.4-59.3; P = 0.001). Conclusions Coffee consumption delayed disease progression in ALD and PSC patients with ESLD and increased long-term survival after liver transplantation. We conclude that regular coffee intake might be recommended for these patients.
DOI:doi:10.1111/jgh.13319
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1111/jgh.13319
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/jgh.13319
 DOI: https://doi.org/10.1111/jgh.13319
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:actuarial survival free of liver transplantation
 coffee consumption
 graft failure
 liver transplantation
 transplantation list
K10plus-PPN:1581602022
Verknüpfungen:→ Zeitschrift

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