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Verfasst von:Takx, Richard A. P. [VerfasserIn]   i
 Pilz, Lothar R. [VerfasserIn]   i
 Schönberg, Stefan [VerfasserIn]   i
 Henzler, Thomas [VerfasserIn]   i
 Apfaltrer, Paul [VerfasserIn]   i
Titel:Coronary artery calcium in breast cancer survivors after radiation therapy
Verf.angabe:Richard A.P. Takx, Rozemarijn Vliegenthart, U. Joseph Schoepf, Lothar R. Pilz, Stefan O. Schoenberg, Pamela B. Morris, Thomas Henzler, Paul Apfaltrer
E-Jahr:2017
Jahr:24 March 2017
Umfang:7 S.
Fussnoten:Gesehen am 08.10.2018
Titel Quelle:Enthalten in: The international journal of cardiovascular imaging
Ort Quelle:Dordrecht [u.a.] : Springer, 2001
Jahr Quelle:2017
Band/Heft Quelle:33(2017), 9, Seite 1425-1431
ISSN Quelle:1875-8312
Abstract:The purpose of the current study is to investigate whether breast cancer survivors after radiation therapy have a higher burden of coronary artery calcium as a potential surrogate of radiation-induced accelerated coronary artery disease. 333 patients were included. 54 patients underwent chest CT ≥ 6 months after the start of radiation therapy (radiation therapy group), while 279 patients had a CT scan either prior to or without undergoing radiation therapy (RT). Coronary artery calcium was quantified from CT by applying a threshold-based automated algorithm. Mean age at diagnosis was similar (p = 0.771) between RT (57.4 ± 13.1 years) and NoRT (58.0 ± 11.9 years). Median time between radiation therapy and CT was 2 years. The groups showed no significant differences in race, smoking history, cancer laterality, or cancer stage. 39 (72.2%) of RT patients had a coronary artery calcium score of 0, compared to 201 (72.0%) in patients without radiation therapy. Median coronary artery calcium burden for both groups was not significantly different (p = 0.982), nor when comparing patients who underwent left- versus right-sided radiation therapy (p = 0.453). When adjusting for the time between diagnosis and CT, radiation therapy patients had a significantly lower risk of a positive coronary artery calcium score. In conclusion, breast cancer survivors after radiation therapy are not more likely to show coronary artery calcium on follow-up CT imaging. Our results thus do not support radiation-induced accelerated coronary artery disease as an explanation for higher rates of heart disease in this group.
DOI:doi:10.1007/s10554-017-1119-x
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1007/s10554-017-1119-x
 Volltext: https://doi.org/10.1007/s10554-017-1119-x
 DOI: https://doi.org/10.1007/s10554-017-1119-x
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Breast neoplasms
 Coronary artery disease
 Myocardial ischemia
 Radiation oncology
 Radiation therapy
K10plus-PPN:1581620845
Verknüpfungen:→ Zeitschrift

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