| Online-Ressource |
Verfasst von: | Takx, Richard A. P. [VerfasserIn]  |
| Pilz, Lothar R. [VerfasserIn]  |
| Schönberg, Stefan [VerfasserIn]  |
| Henzler, Thomas [VerfasserIn]  |
| Apfaltrer, Paul [VerfasserIn]  |
Titel: | Coronary artery calcium in breast cancer survivors after radiation therapy |
Verf.angabe: | Richard A.P. Takx, Rozemarijn Vliegenthart, U. Joseph Schoepf, Lothar R. Pilz, Stefan O. Schoenberg, Pamela B. Morris, Thomas Henzler, Paul Apfaltrer |
E-Jahr: | 2017 |
Jahr: | 24 March 2017 |
Umfang: | 7 S. |
Fussnoten: | Gesehen am 08.10.2018 |
Titel Quelle: | Enthalten in: The international journal of cardiovascular imaging |
Ort Quelle: | Dordrecht [u.a.] : Springer, 2001 |
Jahr Quelle: | 2017 |
Band/Heft Quelle: | 33(2017), 9, Seite 1425-1431 |
ISSN Quelle: | 1875-8312 |
Abstract: | The purpose of the current study is to investigate whether breast cancer survivors after radiation therapy have a higher burden of coronary artery calcium as a potential surrogate of radiation-induced accelerated coronary artery disease. 333 patients were included. 54 patients underwent chest CT ≥ 6 months after the start of radiation therapy (radiation therapy group), while 279 patients had a CT scan either prior to or without undergoing radiation therapy (RT). Coronary artery calcium was quantified from CT by applying a threshold-based automated algorithm. Mean age at diagnosis was similar (p = 0.771) between RT (57.4 ± 13.1 years) and NoRT (58.0 ± 11.9 years). Median time between radiation therapy and CT was 2 years. The groups showed no significant differences in race, smoking history, cancer laterality, or cancer stage. 39 (72.2%) of RT patients had a coronary artery calcium score of 0, compared to 201 (72.0%) in patients without radiation therapy. Median coronary artery calcium burden for both groups was not significantly different (p = 0.982), nor when comparing patients who underwent left- versus right-sided radiation therapy (p = 0.453). When adjusting for the time between diagnosis and CT, radiation therapy patients had a significantly lower risk of a positive coronary artery calcium score. In conclusion, breast cancer survivors after radiation therapy are not more likely to show coronary artery calcium on follow-up CT imaging. Our results thus do not support radiation-induced accelerated coronary artery disease as an explanation for higher rates of heart disease in this group. |
DOI: | doi:10.1007/s10554-017-1119-x |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1007/s10554-017-1119-x |
| Volltext: https://doi.org/10.1007/s10554-017-1119-x |
| DOI: https://doi.org/10.1007/s10554-017-1119-x |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Breast neoplasms |
| Coronary artery disease |
| Myocardial ischemia |
| Radiation oncology |
| Radiation therapy |
K10plus-PPN: | 1581620845 |
Verknüpfungen: | → Zeitschrift |
Coronary artery calcium in breast cancer survivors after radiation therapy / Takx, Richard A. P. [VerfasserIn]; 24 March 2017 (Online-Ressource)