Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Marquez, Herman [VerfasserIn]  |
| Haubenreisser, Holger [VerfasserIn]  |
| Henzler, Thomas [VerfasserIn]  |
Titel: | Computed tomography perfusion imaging for monitoring transarterial chemoembolization of hepatocellular carcinoma |
Verf.angabe: | Herman P. Marquez, Amar Karalli, Holger Haubenreisser, Rishi P. Mathew, Hatem Alkadhi, Torkel B. Brismar, Thomas Henzler, Michael A. Fischer |
E-Jahr: | 2017 |
Jahr: | 24 March 2017 |
Umfang: | 8 S. |
Fussnoten: | Gesehen am 09.10.2018 |
Titel Quelle: | Enthalten in: European journal of radiology |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1990 |
Jahr Quelle: | 2017 |
Band/Heft Quelle: | 91(2017), Seite 160-167 |
ISSN Quelle: | 1872-7727 |
Abstract: | Purpose: To prospectively monitor changes in tumor perfusion of hepatocellular carcinoma (HCC) in response to doxorubicin-eluted bead based transarterial chemoembolization (DEB-TACE) using perfusion-CT (P-CT). Methods and materials: 24 patients (54-79 years) undergoing P-CT before and shortly after DEB-TACE of HCC were prospectively included in this dual-center study. Two readers determined arterial-liver-perfusion (ALP, mL/min/100mL), portal-venous-perfusion (PLP, mL/min/100mL) and the hepatic-perfusion-index (HPI, %) by placing matched regions-of-interests within each HCC before and after DEB-TACE. Imaging follow-up was used to determine treatment response and to distinguish complete from incomplete responders. Performance of P-CT for prediction and early response assessment was determined using receiver-operating-characteristics curve analysis. Results: Interreader agreement was fair to excellent (ICC, 0.716-0.942). PLP before DEB-TACE was significantly higher in pre-treated vs non-treated lesions (P<0.05). Mean changes of ALP, PLP and HPI from before to after DEB-TACE were −55%, +24% and −27%. ALP and HPI after DEB-TACE were correlating with response-grades (r=0.45/0.48; both, p<0.04), showing an area-under-the-curve (AUC) of 0.74 and 0.80 respectively for identification of complete response. Conclusion: High arterial and low portal-venous perfusion of HCC early after DEB-TACE indicates incomplete response with good diagnostic accuracy. |
DOI: | doi:10.1016/j.ejrad.2017.03.014 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.ejrad.2017.03.014 |
| Volltext: http://www.sciencedirect.com/science/article/pii/S0720048X17301146 |
| DOI: https://doi.org/10.1016/j.ejrad.2017.03.014 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Computed tomography |
| Hepatocellular carcinoma |
| Perfusion imaging |
| Transarterial chemoembolization |
| Treatment outcome |
K10plus-PPN: | 1581674732 |
Verknüpfungen: | → Zeitschrift |
Computed tomography perfusion imaging for monitoring transarterial chemoembolization of hepatocellular carcinoma / Marquez, Herman [VerfasserIn]; 24 March 2017 (Online-Ressource)
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