Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Marquez, Herman [VerfasserIn]   i
 Haubenreisser, Holger [VerfasserIn]   i
 Henzler, Thomas [VerfasserIn]   i
Titel:Computed tomography perfusion imaging for monitoring transarterial chemoembolization of hepatocellular carcinoma
Verf.angabe:Herman P. Marquez, Amar Karalli, Holger Haubenreisser, Rishi P. Mathew, Hatem Alkadhi, Torkel B. Brismar, Thomas Henzler, Michael A. Fischer
E-Jahr:2017
Jahr:24 March 2017
Umfang:8 S.
Fussnoten:Gesehen am 09.10.2018
Titel Quelle:Enthalten in: European journal of radiology
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1990
Jahr Quelle:2017
Band/Heft Quelle:91(2017), Seite 160-167
ISSN Quelle:1872-7727
Abstract:Purpose: To prospectively monitor changes in tumor perfusion of hepatocellular carcinoma (HCC) in response to doxorubicin-eluted bead based transarterial chemoembolization (DEB-TACE) using perfusion-CT (P-CT). Methods and materials: 24 patients (54-79 years) undergoing P-CT before and shortly after DEB-TACE of HCC were prospectively included in this dual-center study. Two readers determined arterial-liver-perfusion (ALP, mL/min/100mL), portal-venous-perfusion (PLP, mL/min/100mL) and the hepatic-perfusion-index (HPI, %) by placing matched regions-of-interests within each HCC before and after DEB-TACE. Imaging follow-up was used to determine treatment response and to distinguish complete from incomplete responders. Performance of P-CT for prediction and early response assessment was determined using receiver-operating-characteristics curve analysis. Results: Interreader agreement was fair to excellent (ICC, 0.716-0.942). PLP before DEB-TACE was significantly higher in pre-treated vs non-treated lesions (P<0.05). Mean changes of ALP, PLP and HPI from before to after DEB-TACE were −55%, +24% and −27%. ALP and HPI after DEB-TACE were correlating with response-grades (r=0.45/0.48; both, p<0.04), showing an area-under-the-curve (AUC) of 0.74 and 0.80 respectively for identification of complete response. Conclusion: High arterial and low portal-venous perfusion of HCC early after DEB-TACE indicates incomplete response with good diagnostic accuracy.
DOI:doi:10.1016/j.ejrad.2017.03.014
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.ejrad.2017.03.014
 Volltext: http://www.sciencedirect.com/science/article/pii/S0720048X17301146
 DOI: https://doi.org/10.1016/j.ejrad.2017.03.014
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Computed tomography
 Hepatocellular carcinoma
 Perfusion imaging
 Transarterial chemoembolization
 Treatment outcome
K10plus-PPN:1581674732
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68313251   QR-Code
zum Seitenanfang