| |  Online-Ressource |
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| Verfasst von: | Huse, Jason T. [VerfasserIn]  |
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| | Jones, David T. W. [VerfasserIn] |
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| | Capper, David [VerfasserIn] |
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| | Chavez, Lukas [VerfasserIn] |
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| Titel: | Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) |
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| Titelzusatz: | an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway |
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| Verf.angabe: | Jason T. Huse, Matija Snuderl, David T. W. Jones, Carole D. Brathwaite, Nolan Altman, Ehud Lavi, Richard Saffery, Alexandra Sexton-Oates, Ingmar Blumcke, David Capper, Matthias A. Karajannis, Ryma Benayed, Lukas Chavez, Cheddhi Thomas, Jonathan Serrano, Laetitia Borsu, Marc Ladanyi, Marc K. Rosenblum |
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| Jahr: | 2017 |
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| Umfang: | 13 S. |
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| Teil: | volume:133 |
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| | year:2017 |
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| | number:3 |
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| | pages:417-429 |
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| | extent:13 |
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| Fussnoten: | Published online: 3 November 2016 ; im Zusatz zum HST ist die Zahl "34" tiefgestellt ; Gesehen am 09.10.2018 |
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| Titel Quelle: | Enthalten in: Acta neuropathologica |
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| Ort Quelle: | Berlin : Springer, 1961 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 133(2017), 3, Seite 417-429 |
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| ISSN Quelle: | 1432-0533 |
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| Abstract: | Epileptogenic tumors affecting children and young adults are a morphologically diverse collection of neuroepithelial neoplasms that, as a group, exhibit varying levels of glial and/or neuronal differentiation. Recent advances in molecular profiling technology, including comprehensive DNA sequencing and methylation analysis, have enabled the application of more precise and biologically relevant classification schemes to these tumors. In this report, we describe a morphologically and molecularly distinct epileptogenic neoplasm, the polymorphous low-grade neuroepithelial tumor of the young (PLNTY), which likely accounts for a sizable portion of oligodendroglioma-like tumors affecting the pediatric population. Characteristic microscopic findings most notably include infiltrative growth, the invariable presence of oligodendroglioma-like cellular components, and intense immunolabeling for cluster of differentiation 34 (CD34). Moreover, integrative molecular profiling reveals a distinct DNA methylation signature for PLNTYs, along with frequent genetic abnormalities involving either B-Raf proto-oncogene (BRAF) or fibroblast growth factor receptors 2 and 3 (FGFR2, FGFR3). These findings suggest that PLNTY represents a distinct biological entity within the larger spectrum of pediatric, low-grade neuroepithelial tumors. |
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| DOI: | doi:10.1007/s00401-016-1639-9 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: http://dx.doi.org/10.1007/s00401-016-1639-9 |
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| | Volltext: https://doi.org/10.1007/s00401-016-1639-9 |
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| | DOI: https://doi.org/10.1007/s00401-016-1639-9 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | BRAF |
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| | Epilepsy |
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| | FGFR2 |
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| | FGFR3 |
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| | Low-grade neuroepithelial tumor |
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| | Oligodendroglioma |
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| K10plus-PPN: | 1581693435 |
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| Verknüpfungen: | → Zeitschrift |
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Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) / Huse, Jason T. [VerfasserIn]; 2017 (Online-Ressource)
