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Verfasst von:Wang, Lei [VerfasserIn]   i
 Ni, Ming [VerfasserIn]   i
 Hückelhoven-Krauss, Angela [VerfasserIn]   i
 Sellner, Leopold [VerfasserIn]   i
 Hoffmann, Jean-Marc [VerfasserIn]   i
 Neuber, Brigitte [VerfasserIn]   i
 Luft, Thomas [VerfasserIn]   i
 Hegenbart, Ute [VerfasserIn]   i
 Schönland, Stefan [VerfasserIn]   i
 Kleist, Christian [VerfasserIn]   i
 Sill, Martin [VerfasserIn]   i
 Wuchter, Patrick [VerfasserIn]   i
 Eckstein, Volker [VerfasserIn]   i
 Müller-Tidow, Carsten [VerfasserIn]   i
 Ho, Anthony Dick [VerfasserIn]   i
 Dreger, Peter [VerfasserIn]   i
 Schmitt, Michael [VerfasserIn]   i
 Schmitt, Anita [VerfasserIn]   i
Titel:Modulation of B cells and homing marker on NK cells through extracorporeal photopheresis in patients with steroid-refractory/resistant graft-vs.-host disease without hampering anti-viral/anti-leukemic effects
Verf.angabe:Lei Wang, Ming Ni, Angela Hückelhoven-Krauss, Leopold Sellner, Jean-Marc Hoffmann, Brigitte Neuber, Thomas Luft, Ute Hegenbart, Stefan Schönland, Christian Kleist, Martin Sill, Bao-an Chen, Patrick Wuchter, Volker Eckstein, William Krüger, Inken Hilgendorf, Ronit Yerushalmi, Arnon Nagler, Carsten Müller-Tidow, Anthony D. Ho, Peter Dreger, Michael Schmitt and Anita Schmitt
E-Jahr:2018
Jahr:08 October 2018
Umfang:15 S.
Fussnoten:Gesehen am 11.10.2018
Titel Quelle:Enthalten in: Frontiers in immunology
Ort Quelle:Lausanne : Frontiers Media, 2010
Jahr Quelle:2018
Band/Heft Quelle:9(2018), Artikel-ID 2207
ISSN Quelle:1664-3224
Abstract:Graft-versus-host disease (GvHD), a severe complication of allogeneic hematopoietic stem cell transplantation, significantly affects the post-transplant morbidity and mortality. Systemic steroids remain the gold standard for the initial management of GvHD. However, up to 60% of patients will not sufficiently respond to steroids. Extracorporeal photopheresis (ECP), a cell-based immunotherapy, has shown good clinical results in such steroid-refractory/resistant GvHD patients. Given its immunomodulatory, but not global immunosuppressive and steroid-sparing capacity, ECP constitutes an attractive option. In the case of GvHD, the balance of immune cells is destroyed: effector cells are not any longer efficiently controlled by regulatory cells. ECP therapy may restore this balance. However, the precise mechanism and the impact of ECP on anti-viral/anti-leukemic function remain unclear. In this study, 839 ECP treatments were performed on patients with acute GvHD (aGvHD) and chronic GvHD (cGvHD). A comprehensive analysis of effector and regulatory cells in patients under ECP therapy included multi-parametric flow cytometry and tetramer staining, LuminexTM-based cytokine, interferon-γ enzyme-linked immunospot and chromium-51 release assays. Gene profiling of myeloid-derived suppressor cells (MDSCs) was performed by microarray analysis. Immunologically, modulations of effector and regulatory cells as well as proinflammatory cytokines were observed under ECP treatment: (1) GvHD-relevant cell subsets like CD62L+ NK cells and newly defined CD19hiCD20hi B cells were modulated, but (2) quantity and quality of anti-viral/anti-leukemic effector cells were preserved. (3) The development of MDSCs was promoted and switched from an inactivated subset (CD33-CD11b+) to an activated subset (CD33+CD11b+). (4) The frequency of Foxp3+CD4+ regulatory T cells (Tregs) and CD24+CD38hi regulatory B cells was considerably increased in aGvHD patients, and Foxp3+CD8+ Tregs in cGvHD patients. (5) Proinflammatory cytokines like IL-1β, IL-6, IL-8 and TNF-α were significantly reduced. In summary, ECP constitutes an effective immunomodulatory therapy for patients with steroid-refractory/resistant GvHD without impairment of anti-viral/leukemia effects.
DOI:doi:10.3389/fimmu.2018.02207
URL:kostenfrei: Volltext: http://dx.doi.org/10.3389/fimmu.2018.02207
 kostenfrei: Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2018.02207/full
 DOI: https://doi.org/10.3389/fimmu.2018.02207
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:(1) GvHD
 (2) ECP
 (3) immunomodulation
 (4) regulatory cells
 (5) pro-inflammatory cytokines
 (6) effector cells
 (7) anti-viral effect
 (8) anti-leukemic effect
K10plus-PPN:1581787553
Verknüpfungen:→ Zeitschrift
 
 
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