Status: Bibliographieeintrag
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| Verfasst von: | Bochtler, Tilmann [VerfasserIn]  |
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| | Kirsch, Michael [VerfasserIn] |
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| | Klingmüller, Ursula [VerfasserIn] |
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| | Ho, Anthony Dick [VerfasserIn] |
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| | Krämer, Alwin [VerfasserIn] |
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| Titel: | Centrosomal targeting of tyrosine kinase activity does not enhance oncogenicity in chronic myeloproliferative disorders |
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| Verf.angabe: | T Bochtler, M Kirsch, B Maier, J Bachmann, U Klingmüller, S Anderhub, AD Ho and A Krämer |
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| Jahr: | 2012 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 11.10.2018 ; Published online 21 October 2011 |
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| Titel Quelle: | Enthalten in: Leukemia |
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| Ort Quelle: | London : Springer Nature, 1997 |
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| Jahr Quelle: | 2012 |
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| Band/Heft Quelle: | 26(2012), 4, Seite 728-735 |
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| ISSN Quelle: | 1476-5551 |
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| Abstract: | Constitutive tyrosine kinase activation by reciprocal chromosomal translocation is a common pathogenetic mechanism in chronic myeloproliferative disorders. Since centrosomal proteins have been recurrently identified as translocation partners of tyrosine kinases FGFR1, JAK2, PDGFRα and PDGFRβ in these diseases, a role for the centrosome in oncogenic transformation has been hypothesized. In this study, we addressed the functional role of centrosomally targeted tyrosine kinase activity. First, centrosomal localization was not routinely found for all chimeric fusion proteins tested. Second, targeting of tyrosine kinases to the centrosome by creating artificial chimeric fusion kinases with the centrosomal targeting domain of AKAP450 failed to enhance the oncogenic transforming potential in both Ba/F3 and U2OS cells, although phospho-tyrosine-mediated signal transduction pathways were initiated at the centrosome. We conclude that the centrosomal localization of constitutively activated tyrosine kinases does not contribute to disease pathogenesis in chronic myeloproliferative disorders. |
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| DOI: | doi:10.1038/leu.2011.283 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: http://dx.doi.org/10.1038/leu.2011.283 |
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| | Volltext: https://www.nature.com/articles/leu2011283 |
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| | DOI: https://doi.org/10.1038/leu.2011.283 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1581760515 |
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| Verknüpfungen: | → Zeitschrift |
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Centrosomal targeting of tyrosine kinase activity does not enhance oncogenicity in chronic myeloproliferative disorders / Bochtler, Tilmann [VerfasserIn]; 2012 (Online-Ressource)
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