Molecular mechanisms and therapeutic targets in pediatric brain tumors

• Verfasst von: Liu, Kun-Wei [VerfasserIn]
• Verfasst von: Pajtler, Kristian Wilfried [VerfasserIn]
• Verfasst von: Jones, Barbara Christine [VerfasserIn]
• Verfasst von: Pfister, Stefan [VerfasserIn]
• Titel: Molecular mechanisms and therapeutic targets in pediatric brain tumors
• Verf.angabe: Kun-Wei Liu, Kristian W. Pajtler, Barbara C. Worst, Stefan M. Pfister, Robert J. Wechsler-Reya
• E-Jahr: 2017
• Jahr: 14 March 2017
• Umfang: 20 S.
• Teil: volume:10
• Teil: year:2017
• Teil: number:470
• Teil: elocationid:eaaf7593
• Teil: extent:20
• Fussnoten: Gesehen am 16.10.2018
• Titel Quelle: Enthalten in: Science signaling
• Ort Quelle: Washington, DC [u.a.] : Assoc., 2008
• Jahr Quelle: 2017
• Band/Heft Quelle: 10(2017), 470, Artikel-ID eaaf7593
• ISSN Quelle: 1937-9145
• DOI: doi:10.1126/scisignal.aaf7593
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1581961618

Abstract

Brain tumors are the leading cause of cancer-related deaths in children, and therapies are few and cause devastating long-term side effects. Genomics and epigenomics have revealed that these tumors are molecularly diverse and appear to be driven by mutations in various signaling pathways, which may present new opportunities for a more targeted therapeutic intervention. In this Review, which contains three figures and 224 references, we discuss our current understanding of the molecular basis of the three most common malignant pediatric brain tumors (medulloblastoma, ependymoma, and high-grade glioma) and the prospects for developing safer and more effective therapies.