Predicting hospitalization and mortality in patients with heart failure

• Verfasst von: Uszko-Lencer, Nicole H.M.K. [VerfasserIn]
• Verfasst von: Frankenstein, Lutz [VerfasserIn]
• Verfasst von: Zugck, Christian [VerfasserIn]
• Titel: Predicting hospitalization and mortality in patients with heart failure
• Titelzusatz: the BARDICHE-index
• Verf.angabe: Nicole H.M.K. Uszko-Lencer, Lutz Frankenstein, Martijn A. Spruit, Micha T. Maeder, Marc Gutmann, Stefano Muzzarelli, Stefan Osswald, Matthias E. Pfisterer, Christian Zugck, Hans-Peter Brunner-La Rocca, the TIME-CHF Investigators
• Jahr: 2017
• Jahr des Originals: 2016
• Umfang: 7 S.
• Teil: volume:227
• Teil: year:2017
• Teil: pages:901-907
• Teil: extent:7
• Fussnoten: Gesehen am 17.10.2018 ; Article was first available online on 9 November 2016
• Titel Quelle: Enthalten in: International journal of cardiology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1981
• Jahr Quelle: 2017
• Band/Heft Quelle: 227(2017), Seite 901-907
• ISSN Quelle: 1874-1754
• DOI: doi:10.1016/j.ijcard.2016.11.122
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Chronic heart failure
• Sach-SW: Prognostic model
• Sach-SW: Survival
• K10plus-PPN: 1582045860

Abstract

Background - Prediction of events in chronic heart failure (CHF) patients is still difficult and available scores are often complex to calculate. Therefore, we developed and validated a simple-to-use, multidimensional prognostic index for such patients. - Methods - A theoretical model was developed based on known prognostic factors of CHF that are easily obtainable: Body mass index (B), Age (A), Resting systolic blood pressure (R), Dyspnea (D), N-termInal pro brain natriuretic peptide (NT-proBNP) (I), Cockroft-Gault equation to estimate glomerular filtration rate (C), resting Heart rate (H), and Exercise performance using the 6-min walk test (E) (the BARDICHE-index). Scores were given for all components and added, the sum ranging from 1 (lowest value) to 25 points (maximal value), with estimated risk being highest in patients with highest scores. Scores were categorized into three groups: a low (≤8 points); medium (9-16 points), or high (>16 points) BARDICHE-score. The model was validated in a data set of 1811 patients from two prospective CHF-cohorts (median follow-up 887days). The primary outcome was 5-year all-cause survival. Secondary outcomes were 5-year survival without all-cause hospitalization and 5-year survival without CHF-related hospitalization. - Results - There were significant differences between BARDICHE-risk groups for mortality (hazard ratio=3.63 per BARDICHE-group, 95%-CI 3.10-4.25), mortality or all-cause hospitalization (HR=2.00 per BARDICHE-group, 95%-CI 1.83-2.19), and mortality or CHF-related hospitalization (HR=3.43 per BARDICHE-group, 95%-CI 3.01-3.92; all P<10-50). Outcome was predicted independently of left ventricular ejection fraction (LVEF) and gender. - Conclusions - The BARDICHE-index is a simple multidimensional prognostic tool for patients with CHF, independently of LVEF.