Status: Bibliographieeintrag
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| Verfasst von: | Götz, Nicola [VerfasserIn]  |
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| | Fritz, Joëlle [VerfasserIn] |
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| | Fackler, Oliver Till [VerfasserIn] |
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| Titel: | Reacquisition of nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee host |
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| Verf.angabe: | Nicola Götz, Daniel Sauter, Shariq M. Usmani, Joëlle V. Fritz, Christine Goffinet, Anke Heigele, Matthias Geyer, Frederic Bibollet-Ruche, Gerald H. Learn, Oliver T. Fackler, Beatrice H. Hahn, and Frank Kirchhoff |
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| E-Jahr: | 2012 |
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| Jahr: | 13 September 2012 |
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| Umfang: | 8 S. |
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| Fussnoten: | Available online 12 September 2012 ; Gesehen am 06.12.2018 |
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| Titel Quelle: | Enthalten in: Cell host and microbe |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 2007 |
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| Jahr Quelle: | 2012 |
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| Band/Heft Quelle: | 12(2012), 3, Seite 373-380 |
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| ISSN Quelle: | 1934-6069 |
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| Abstract: | Summary. The interferon-induced host restriction factor tetherin poses a barrier for SIV transmission from primates to humans. After cross-species transmission, the chimpanzee precursor of pandemic HIV-1 switched from the accessory protein Nef to Vpu to effectively counteract human tetherin. As we report here, the experimental reintroduction of HIV-1 into its original chimpanzee host resulted in a virus that can use both Vpu and Nef to antagonize chimpanzee tetherin. Functional analyses demonstrated that alterations in and near the highly conserved ExxxLL motif in the C-terminal loop of Nef were critical for the reacquisition of antitetherin activity. Strikingly, just two amino acid changes allowed HIV-1 Nef to counteract chimpanzee tetherin and promote virus release. Our data demonstrate that primate lentiviruses can reacquire lost accessory gene functions during a single in vivo passage and suggest that other functional constraints keep Nef ready to regain antitetherin activity. |
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| DOI: | doi:10.1016/j.chom.2012.07.008 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.chom.2012.07.008 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S1931312812002417 |
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| | DOI: https://doi.org/10.1016/j.chom.2012.07.008 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1582059993 |
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| Verknüpfungen: | → Zeitschrift |
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Reacquisition of nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee host / Götz, Nicola [VerfasserIn]; 13 September 2012 (Online-Ressource)
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