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Verfasst von:Wurster, Elena Felicia [VerfasserIn]   i
 Tenckhoff, Solveig [VerfasserIn]   i
 Probst, Pascal [VerfasserIn]   i
 Jensen, Katrin [VerfasserIn]   i
 Dölger, Eva [VerfasserIn]   i
 Knebel, Phillip [VerfasserIn]   i
 Diener, Markus K. [VerfasserIn]   i
 Büchler, Markus W. [VerfasserIn]   i
 Ulrich, Alexis [VerfasserIn]   i
Titel:A systematic review and meta-analysis of the utility of repeated versus single hepatic resection for colorectal cancer liver metastases
Verf.angabe:Elena F. Wurster, Solveig Tenckhoff, Pascal Probst, Katrin Jensen, Eva Dölger, Phillip Knebel, Markus K. Diener, Markus W. Büchler & Alexis Ulrich
E-Jahr:2017
Jahr:June 2017
Umfang:7 S.
Fussnoten:Available online 25 March 2017 ; Gesehen am 23.10.2018
Titel Quelle:Enthalten in: HPB
Ort Quelle:[London] : Elsevier, 1999
Jahr Quelle:2017
Band/Heft Quelle:19(2017), 6, Seite 491-497
ISSN Quelle:1477-2574
Abstract:Background Recurrence of colorectal liver metastases after a first hepatectomy is common (4-48% of patients). This review investigates the utility of repeated hepatic resection of colorectal liver metastases. MethodsA systematic search of the literature was performed in the Cochrane Library, MEDLINE, EMBASE, and trial registers. All studies comparing repeated hepatic resection for colorectal liver metastases with patients who underwent only one hepatectomy were eligible. Outcome criteria were safety parameters and survival rates. Data were analyzed using the random-effects model.Results In eight observational clinical studies, 450 patients with repeated hepatic resection were compared with 2669 single hepatic resections. Morbidity such as hepatic insufficiency (OR [95% CI] 1.46 [0.69; 3.08], p = 0.32) and biliary leakage and fistula (OR [95% CI] 1.22 [0.80; 1.85], p = 0.35) was comparable between the two groups. Mortality (OR [95% CI] 1.13 [0.46; 2.74], p = 0.79) and overall survival (HR [95% CI] 1.00 [0.63; 1.60], p = 0.99) were not significantly different between the two groups. Discussion Repeated hepatic resection for colorectal liver metastases is safe in selected patients. A prospective, multicenter high-quality trial or register study of repeated hepatic resection will be required to clarify patient-oriented outcomes such as overall survival and quality of life.
DOI:doi:10.1016/j.hpb.2017.02.440
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.hpb.2017.02.440
 Volltext: http://www.sciencedirect.com/science/article/pii/S1365182X17305154
 DOI: https://doi.org/10.1016/j.hpb.2017.02.440
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1582140286
Verknüpfungen:→ Zeitschrift

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