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Verfasst von:Vasic, Nenad [VerfasserIn]   i
 Wolf, Robert Christian [VerfasserIn]   i
Titel:Cerebrospinal fluid biomarker candidates of schizophrenia
Titelzusatz:where do we stand?
Verf.angabe:Nenad Vasic, Bernhard J. Connemann, Robert C. Wolf, Hayrettin Tumani, Johannes Brettschneider
Jahr des Originals:2011
Umfang:17 S.
Fussnoten:Published online: 16 December 2011 ; Gesehen am 22.10.2018
Titel Quelle:Enthalten in: European archives of psychiatry and clinical neuroscience
Jahr Quelle:2012
Band/Heft Quelle:262(2012), 5, S. 375-391
ISSN Quelle:1433-8491
Abstract:Here, we review the cerebrospinal fluid (CSF) candidate markers with regard to their clinical relevance as potential surrogates for disease activity, prognosis assessment, and predictors of treatment response. We searched different online databases such as MEDLINE and EMBASE for studies on schizophrenia and CSF. Initial studies on cerebrospinal fluid in patients with schizophrenia revealed increased brain-blood barrier permeability with elevated total protein content, increased CSF-to-serum ratio for albumin, and intrathecal production of immunoglobulins in subgroups of patients. Analyses of metabolites in CSF suggest alterations within glutamatergic neurotransmission as well as monoamine and cannabinoid metabolism. Decreased levels of brain-derived neurotrophic factor and nerve growth factor in CSF of first-episode patients with schizophrenia reported in recent studies point to a dysregulation of neuroprotective and neurodevelopmental processes. Still, these findings must beconsidered as non-specific. A more profound characterization of the particular psychopathological profiles, the investigation of patients in the prodromal phase or within the first episode of schizophrenia promoting longitudinal investigations, implementation of different approaches of proteomics, and rigorous adherence to standard procedures based on international CSF guidelines are necessary to improve the quality of CSF studies in schizophrenia, paving the way for identification of syndrome-specific biomarker candidates.
DOI:doi:10.1007/s00406-011-0280-9
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Verlag: http://dx.doi.org/10.1007/s00406-011-0280-9
 Verlag: https://doi.org/10.1007/s00406-011-0280-9
 DOI: https://doi.org/10.1007/s00406-011-0280-9
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:158214558X
Verknüpfungen:→ Zeitschrift

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