Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Xiang, Jinyi [VerfasserIn]  |
| Zhang, Peng [VerfasserIn]  |
| Jin, Yinhua [VerfasserIn]  |
| Edgar, Bruce [VerfasserIn]  |
Titel: | EGFR-dependent TOR-independent endocycles support Drosophila gut epithelial regeneration |
Verf.angabe: | Jinyi Xiang, Jennifer Bandura, Peng Zhang, Yinhua Jin, Hanna Reuter & Bruce A. Edgar |
E-Jahr: | 2017 |
Jahr: | 09 May 2017 |
Umfang: | 13 S. |
Teil: | volume:8 |
| year:2017 |
| elocationid:15125 |
| extent:13 |
Fussnoten: | Gesehen am 22.10.2018 |
Titel Quelle: | Enthalten in: Nature Communications |
Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
Jahr Quelle: | 2017 |
Band/Heft Quelle: | 8(2017), Artikel-ID 15125 |
ISSN Quelle: | 2041-1723 |
Abstract: | Following gut epithelial damage, epidermal growth factor receptor/mitogen-activated protein kinase (EGFR/MAPK) signalling triggers Drosophila intestinal stem cells to produce enteroblasts (EBs) and enterocytes (ECs) that regenerate the gut. As EBs differentiate into ECs, they become postmitotic, but undergo extensive growth and DNA endoreplication. Here we report that EGFR/RAS/MAPK signalling is required and sufficient to drive damage-induced EB/EC growth. Endoreplication occurs exclusively in EBs and newborn ECs that inherit EGFR and active MAPK from fast-dividing progenitors. Mature ECs lack EGF receptors and are refractory to growth signalling. Genetic tests indicated that stress-dependent EGFR/MAPK promotes gut regeneration via a novel mechanism that operates independently of Insulin/Pi3K/TOR signalling, which is nevertheless required in nonstressed conditions. The E2f1 transcription factor is required for and sufficient to drive EC endoreplication, and Ras/Raf signalling upregulates E2f1 levels posttranscriptionally. We illustrate how distinct signalling mechanisms direct stress-dependent versus homeostatic regeneration, and highlight the importance of postmitotic cell growth in gut epithelial repair. |
DOI: | doi:10.1038/ncomms15125 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext ; Verlag: http://dx.doi.org/10.1038/ncomms15125 |
| kostenfrei: Volltext: https://www.nature.com/articles/ncomms15125 |
| DOI: https://doi.org/10.1038/ncomms15125 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1582149429 |
Verknüpfungen: | → Zeitschrift |
EGFR-dependent TOR-independent endocycles support Drosophila gut epithelial regeneration / Xiang, Jinyi [VerfasserIn]; 09 May 2017 (Online-Ressource)
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