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Status: Bibliographieeintrag

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Verfasst von:Abba, Mohammed L. [VerfasserIn]   i
 Mudduluru, Giridhar [VerfasserIn]   i
 Allgayer, Heike [VerfasserIn]   i
Titel:MicroRNAs in cancer
Titelzusatz:small molecules, big chances
Verf.angabe:Mohammed Abba, Giridhar Mudduluru and Heike Allgayer
Jahr:2012
Umfang:11 S.
Fussnoten:Gesehen am 22.10.2018
Titel Quelle:Enthalten in: Anti-cancer agents in medicinal chemistry
Ort Quelle:Sharjah : Bentham Sc. Publ., 2006
Jahr Quelle:2012
Band/Heft Quelle:12(2012), 7, Seite 733-743
ISSN Quelle:1875-5992
Abstract:MicroRNAs have come to represent a significant mechanism of post transcriptional gene regulation affecting processes as varied as cellular differentiation, proliferation, metabolism, apoptosis, and cancer. As more miRNAs are unravelled and their roles dissected, it has become evident that the involvement of these molecules in cancer is much more extensive than initially thought. Several miRNA expression analyses in both haematological malignancies and solid tumors have shown that, aside significant differences in expression between tumor and normal states, distinct tumor specific miRNA signatures exist. Additionally, the ability of miRNAs to mediate both oncogenic and tumor suppressor functions further broadens their functional significance. In recent years, efforts have intensified to utilize miRNAs therapeutically, especially in the context of oncomirs. As far as the impact and the success of this approach are concerned, it is still early days, but the potential is enormous. This review focuses on the important miRNAs that have been found to impact the tumorigenic process, how far we have come in terms of utilizing these molecules for therapy and the outlook for the near future.
DOI:doi:10.2174/187152012802650273
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.2174/187152012802650273
 Volltext: http://www.eurekaselect.com.ezproxy.medma.uni-heidelberg.de/102220/article
 DOI: https://doi.org/10.2174/187152012802650273
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1582152209
Verknüpfungen:→ Zeitschrift

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