BID links ferroptosis to mitochondrial cell death pathways

• Verfasst von: Neitemeier, Sandra [VerfasserIn]
• Verfasst von: Oppermann, Sina [VerfasserIn]
• Titel: BID links ferroptosis to mitochondrial cell death pathways
• Verf.angabe: Sandra Neitemeier, Anja Jelinek, Vincenzo Laino, Lena Hoffmann, Ina Eisenbach, Roman Eying, Goutham K. Ganjam, Amalia M. Dolga, Sina Oppermann, Carsten Culmsee
• E-Jahr: 2017
• Jahr: August 2017
• Umfang: 13 S.
• Teil: volume:12
• Teil: year:2017
• Teil: pages:558-570
• Teil: extent:13
• Fussnoten: Available online 9 March 2017 ; Gesehen am 22.10.2018
• Titel Quelle: Enthalten in: Redox Biology
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 2013
• Jahr Quelle: 2017
• Band/Heft Quelle: 12(2017), Seite 558-570
• ISSN Quelle: 2213-2317
• DOI: doi:10.1016/j.redox.2017.03.007
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1582160279

Abstract

Ferroptosis has been defined as an oxidative and iron-dependent pathway of regulated cell death that is distinct from caspase-dependent apoptosis and established pathways of death receptor-mediated regulated necrosis. While emerging evidence linked features of ferroptosis induced e.g. by erastin-mediated inhibition of the Xc- system or inhibition of glutathione peroxidase 4 (Gpx4) to an increasing number of oxidative cell death paradigms in cancer cells, neurons or kidney cells, the biochemical pathways of oxidative cell death remained largely unclear. In particular, the role of mitochondrial damage in paradigms of ferroptosis needs further investigation.