Deciphering a global network of functionally associated post-translational modifications

• Verfasst von: Minguez, Pablo [VerfasserIn]
• Verfasst von: Mende, Daniel Richard [VerfasserIn]
• Verfasst von: Gavin, Anne-Claude [VerfasserIn]
• Verfasst von: Bork, Peer [VerfasserIn]
• Titel: Deciphering a global network of functionally associated post-translational modifications
• Verf.angabe: Pablo Minguez, Luca Parca, Francesca Diella, Daniel R Mende, Runjun Kumar, Manuela Helmer-Citterich, Anne-Claude Gavin, Vera van Noort and Peer Bork
• E-Jahr: 2012
• Jahr: 2012 Jul 17
• Umfang: 14 S.
• Teil: volume:8
• Teil: year:2012
• Teil: elocationid:599
• Teil: extent:14
• Fussnoten: Gesehen am 23.10.2018
• Titel Quelle: Enthalten in: Molecular systems biology
• Ort Quelle: Heidelberg : EMBO Press, 2005
• Jahr Quelle: 2012
• Band/Heft Quelle: 8(2012), Artikel-ID 599
• ISSN Quelle: 1744-4292
• DOI: doi:10.1038/msb.2012.31
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1582185832

Abstract

Various post-translational modifications (PTMs) fine-tune the functions of almost all eukaryotic proteins, and co-regulation of different types of PTMs has been shown within and between a number of proteins. Aiming at a more global view of the interplay between PTM types, we collected modifications for 13 frequent PTM types in 8 eukaryotes, compared their speed of evolution and developed a method for measuring PTM co-evolution within proteins based on the co-occurrence of sites across eukaryotes. As many sites are still to be discovered, this is a considerable underestimate, yet, assuming that most co-evolving PTMs are functionally associated, we found that PTM types are vastly interconnected, forming a global network that comprise in human alone >50,000 residues in about 6000 proteins. We predict substantial PTM type interplay in secreted and membrane-associated proteins and in the context of particular protein domains and short-linear motifs. The global network of co-evolving PTM types implies a complex and intertwined post-translational regulation landscape that is likely to regulate multiple functional states of many if not all eukaryotic proteins.