Association of activity changes in the primary sensory cortex with successful motor rehabilitation of the hand following stroke

• Verfasst von: Laible, Mona [VerfasserIn]
• Titel: Association of activity changes in the primary sensory cortex with successful motor rehabilitation of the hand following stroke
• Verf.angabe: Mona Laible, MD, Steven Grieshammer, MD, Gundula Seidel, PhD, Michel Rijntjes, MD, Cornelius Weiller, MD, and Farsin Hamzei, MD
• Umfang: 8 S.
• Fussnoten: Gesehen am 25.10.2018
• Titel Quelle: Enthalten in: Neurorehabilitation and neural repair
• Jahr Quelle: 2012
• Band/Heft Quelle: 26(2012), 7, S. 881-888
• ISSN Quelle: 1552-6844
• DOI: doi:10.1177/1545968312437939
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1582279020

Abstract

Background: Previous studies demonstrated a posterior shift of activation toward the primary sensory cortex (S1) following stroke; however, any relationship between this posterior shift and clinical outcome measures for the affected hand function were unclear. Objective: The authors investigated the possible role of S1 in motor recovery. Methods: Assuming that previous studies examined inhomogeneous groups of patients, the authors selected participants with chronic stroke who had moderate hand paresis, normal sensory examination and somatosensory-evoked potentials, and no lesion within the S1, thalamus, or brain stem. Constraint-induced movement therapy (CIMT) was used to train the impaired hand. To relate fMRI (functional MRI) activation changes from baseline to post-CIMT, a correlation analysis was performed with changes of the Wolf Motor Function Test (WMFT) as a test for the hand function. Results: A close relationship was found between increases in hand function and peakchanges in activation within the ipsilesional S1. With a better outcome, greater increases in activation within the S1 were evident (P < .03; r = 0.73). Conclusion: In selected patients, the sensory network influences training-induced motor gains. This predictive knowledge of plasticity when applying CIMT may suggest strategies to enhance the effect of therapy, such as the addition of electrical stimulation to enhance S1 excitability.