| Online-Ressource |
Verfasst von: | Lahdou, Imad [VerfasserIn]  |
| Sadeghi, Mahmoud [VerfasserIn]  |
| Oweira, Hani [VerfasserIn]  |
| Fusch, Gerhard [VerfasserIn]  |
| Daniel, Volker [VerfasserIn]  |
| Mehrabi, Arianeb [VerfasserIn]  |
| Jung, Gregor Eric [VerfasserIn]  |
| Elhadedy, Hazem [VerfasserIn]  |
| Schmidt, Jan [VerfasserIn]  |
| Şandra-Petrescu, Flavius Ionuţ [VerfasserIn]  |
| Iancu, Mircea [VerfasserIn]  |
| Opelz, Gerhard [VerfasserIn]  |
| Terness, Peter [VerfasserIn]  |
| Schefold, Joerg C. [VerfasserIn]  |
Titel: | Increased serum levels of quinolinic acid indicate enhanced severity of hepatic dysfunction in patients with liver cirrhosis |
Verf.angabe: | Imad Lahdou, Mahmoud Sadeghi, Hani Oweira, Gerhard Fusch, Volker Daniel, Arianeb Mehrabi, GE. Jung, Hazem Elhadedy, Jan Schmidt, Flavius Sandra-Petrescu, Mircea Iancu, Gerhard Opelz, Peter Terness, Joerg C. Schefold |
Jahr: | 2013 |
Umfang: | 7 S. |
Fussnoten: | Available online 6 October 2012 ; Gesehen am 21.09.2021 |
Titel Quelle: | Enthalten in: Human immunology |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1980 |
Jahr Quelle: | 2013 |
Band/Heft Quelle: | 74(2013), 1 vom: Jan., Seite 60-66 |
ISSN Quelle: | 1879-1166 |
Abstract: | Background: The Model for End-Stage Liver Disease (MELD) score is a tool for assessment of the degree of hepatic insufficiency/failure. Quinolinic acid (QuinA) is a tryptophan metabolite produced by activated macrophages. Here we investigate whether the degree of systemic inflammation (QuinA, neopterin, CRP and IL-6) correlates with clinical liver dysfunction according to the MELD Score. Method: Ninety-four patients with liver cirrhosis were categorized into 2 groups according to baseline MELD score (group I, MELD <20, n=61, and group II, MELD ⩾20, n=33). Results: Serum levels of QuinA, neopterin, CRP, and IL-6 significantly correlated with MELD score (r=0.77, 0.75, 0.57, and 0.50; p<0.0001, respectively). Patients of group II had significantly higher serum levels of QuinA, neopterin, CRP, and IL-6 than group I (p⩽0.0001). ROC curve analysis showed that QuinA and neopterin are more sensitive markers for severity of liver disease than established markers of inflammation such as CRP and IL-6 (sensitivity=86% and 79%, respectively) (AUC=0.89 and 0.89, respectively). QuinA provided the most sensitive index with regard to the identification of patients with hepatic encephalopathy. Conclusion: Serum levels of QuinA reflect the degree of liver dysfunction. Moreover, high levels of QuinA may serve as a sensitive indicator of hepatic encephalopathy. |
DOI: | doi:10.1016/j.humimm.2012.09.009 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.humimm.2012.09.009 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S0198885912005605 |
| DOI: https://doi.org/10.1016/j.humimm.2012.09.009 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1582286531 |
Verknüpfungen: | → Zeitschrift |
Increased serum levels of quinolinic acid indicate enhanced severity of hepatic dysfunction in patients with liver cirrhosis / Lahdou, Imad [VerfasserIn]; 2013 (Online-Ressource)