Prefrontal cortical control of a brainstem social behavior circuit

• Verfasst von: Franklin, Tamara [VerfasserIn]
• Verfasst von: Grinevich, Valéry [VerfasserIn]
• Titel: Prefrontal cortical control of a brainstem social behavior circuit
• Verf.angabe: Tamara B. Franklin, Bianca A. Silva, Zina Perova, Livia Marrone, Maria E. Masferrer, Yang Zhan, Angie Kaplan, Louise Greetham, Violaine Verrechia, Andreas Halman, Sara Pagella, Alexei L. Vyssotski, Anna Illarionova, Valery Grinevich, Tiago Branco, & Cornelius T. Gross
• Jahr: 2017
• Umfang: 11 S.
• Fussnoten: Gesehen am 29.10.2018 ; Author manuscript available in PMC 2017 September 01
• Titel Quelle: Enthalten in: Nature neuroscience
• Ort Quelle: New York, NY : Nature America, 1998
• Jahr Quelle: 2017
• Band/Heft Quelle: 20(2017), 2, Seite 260-270
• ISSN Quelle: 1546-1726
• DOI: doi:10.1038/nn.4470
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1582362998

Abstract

The prefrontal cortex plays a critical role in adjusting an organism's behavior to its environment. In particular, numerous studies have implicated the prefrontal cortex in the control of social behavior, but the neural circuits that mediate these effects remain unknown. Here we investigated behavioral adaptation to social defeat in mice and uncovered a critical contribution of neural projections from the medial prefrontal cortex to the dorsal periaqueductal grey, a brainstem area vital for defensive responses. Social defeat caused a weakening of functional connectivity between these two areas and selective inhibition of these projections mimicked the behavioral effects of social defeat. These findings define a specific neural projection by which the prefrontal cortex can control and adapt social behavior.