Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Woitzik, Johannes [VerfasserIn]   i
 Münch, Elke [VerfasserIn]   i
 Schmiedek, Peter [VerfasserIn]   i
Titel:Delayed cerebral ischemia and spreading depolarization in absence of angiographic vasospasm after subarachnoid hemorrhage
Verf.angabe:Johannes Woitzik, Jens P Dreier, Nils Hecht, Ingo Fiss, Nora Sandow, Sebastian Major, Maren Winkler, Yuliya A Dahlem, Jerome Manville, Michael Diepers, Elke Muench, Hidetoshi Kasuya, Peter Schmiedek, Peter Vajkoczy
E-Jahr:2011
Jahr:February 1, 2012
Umfang:10 S.
Fussnoten:Published online 7 December 2011 ; Gesehen am 29.10.2018
Titel Quelle:Enthalten in: Journal of cerebral blood flow & metabolism
Ort Quelle:Thousands Oaks, Calif. : Sage, 1981
Jahr Quelle:2012
Band/Heft Quelle:32(2012), 2, Seite 203-212
ISSN Quelle:1559-7016
Abstract:It has been hypothesized that vasospasm is the prime mechanism of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). Recently, it was found that clusters of spreading depolarizations (SDs) are associated with DCI. Surgical placement of nicardipine prolonged-release implants (NPRIs) was shown to strongly attenuate vasospasm. In the present study, we tested whether SDs and DCI are abolished when vasospasm is reduced or abolished by NPRIs. After aneurysm clipping, 10 NPRIs were placed next to the proximal intracranial vessels. The SDs were recorded using a subdural electrode strip. Proximal vasospasm was assessed by digital subtraction angiography (DSA). 534 SDs were recorded in 10 of 13 patients (77%). Digital subtraction angiography revealed no vasospasm in 8 of 13 patients (62%) and only mild or moderate vasospasm in the remaining. Five patients developed DCI associated with clusters of SD despite the absence of angiographic vasospasm in three of those patients. The number of SDs correlated significantly with the development of DCI. This may explain why reduction of angiographic vasospasm alone has not been sufficient to improve outcome in some clinical studies.
DOI:doi:10.1038/jcbfm.2011.169
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1038/jcbfm.2011.169
 Volltext: https://doi.org/10.1038/jcbfm.2011.169
 DOI: https://doi.org/10.1038/jcbfm.2011.169
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1582374333
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68322694   QR-Code
zum Seitenanfang