Status: Bibliographieeintrag
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| Verfasst von: | Kougioumtzidou, Eleni [VerfasserIn]  |
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| | Sprengel, Rolf [VerfasserIn] |
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| | Monyer, Hannah [VerfasserIn] |
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| Titel: | Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival |
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| Verf.angabe: | Eleni Kougioumtzidou, Takahiro Shimizu, Nicola B Hamilton, Koujiro Tohyama, Rolf Sprengel, Hannah Monyer, David Attwell, William D Richardson |
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| E-Jahr: | 2017 |
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| Jahr: | 13 June 2017 |
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| Umfang: | 31 S. |
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| Fussnoten: | Gesehen am 30.10.2018 |
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| Titel Quelle: | Enthalten in: eLife |
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| Ort Quelle: | Cambridge : eLife Sciences Publications, 2012 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 6(2017), Artikel-ID e28080 |
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| ISSN Quelle: | 2050-084X |
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| Abstract: | Myelin, made by oligodendrocytes, is essential for rapid information transfer in the central nervous system. Oligodendrocyte precursors (OPs) receive glutamatergic synaptic input from axons but how this affects their development is unclear. Murine OPs in white matter express AMPA receptor (AMPAR) subunits GluA2, GluA3 and GluA4. We generated mice in which OPs lack both GluA2 and GluA3, or all three subunits GluA2/3/4, which respectively reduced or abolished AMPAR-mediated input to OPs. In both double- and triple-knockouts OP proliferation and number were unchanged but ~25% fewer oligodendrocytes survived in the subcortical white matter during development. In triple knockouts, this shortfall persisted into adulthood. The oligodendrocyte deficit resulted in ~20% fewer myelin sheaths but the average length, number and thickness of myelin internodes made by individual oligodendrocytes appeared normal. Thus, AMPAR-mediated signalling from active axons stimulates myelin production in developing white matter by enhancing oligodendrocyte survival, without influencing myelin synthesis per se. |
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| DOI: | doi:10.7554/eLife.28080 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.7554/eLife.28080 |
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| | Volltext: https://doi.org/10.7554/eLife.28080 |
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| | DOI: https://doi.org/10.7554/eLife.28080 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | survival |
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| | AMPA receptor |
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| | conditional knockout |
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| | glutamate |
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| | internode length |
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| | oligodendrocyte |
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| K10plus-PPN: | 1582423636 |
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| Verknüpfungen: | → Zeitschrift |
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Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival / Kougioumtzidou, Eleni [VerfasserIn]; 13 June 2017 (Online-Ressource)
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