Left ventricular diastolic function in type 2 diabetes mellitus is associated with myocardial triglyceride content but not with impaired myocardial perfusion reserve

• Verfasst von: Korosoglou, Grigorios [VerfasserIn]
• Verfasst von: Humpert, Per Magnus [VerfasserIn]
• Verfasst von: Ahrens, Johannes [VerfasserIn]
• Verfasst von: Oikonomou, Dimitrios [VerfasserIn]
• Verfasst von: Gitsioudis, Gitsios [VerfasserIn]
• Verfasst von: Buß, Sebastian Johannes [VerfasserIn]
• Verfasst von: Steen, Henning [VerfasserIn]
• Verfasst von: Bierhaus, Angelika [VerfasserIn]
• Verfasst von: Nawroth, Peter Paul [VerfasserIn]
• Verfasst von: Katus, Hugo [VerfasserIn]
• Titel: Left ventricular diastolic function in type 2 diabetes mellitus is associated with myocardial triglyceride content but not with impaired myocardial perfusion reserve
• Verf.angabe: Grigorios Korosoglou, Per M. Humpert, Johannes Ahrens, Dimitrios Oikonomou, Nael F. Osman, Gitsios Gitsioudis, Sebastian J. Buss, Henning Steen, Bernhardt Schnackenburg, Angelika Bierhaus, Peter P. Nawroth, and Hugo A. Katus
• E-Jahr: 2012
• Jahr: June 26, 2012
• Umfang: 8 S.
• Fussnoten: First published: 08 November 2011 ; Gesehen am 30.10.2018
• Titel Quelle: Enthalten in: Journal of magnetic resonance imaging
• Ort Quelle: New York, NY : Wiley-Liss, 1991
• Jahr Quelle: 2012
• Band/Heft Quelle: 35(2012), 4, Seite 804-811
• ISSN Quelle: 1522-2586
• DOI: doi:10.1002/jmri.22879
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: diastolic function
• Sach-SW: myocardial triglyceride content
• Sach-SW: strain-encoded MRI
• Sach-SW: type 2 diabetes mellitus
• Sach-SW: vascular function
• K10plus-PPN: 1582426511

Abstract

Purpose: To study myocardial perfusion reserve and myocellular metabolic alterations indicated by triglyceride content as possible causes of diastolic dysfunction in patients with type 2 diabetes mellitus, preserved systolic function, and without clinically evident coronary artery disease. Materials and Methods: Patients with type 2 diabetes mellitus (n = 42) underwent cardiac magnetic resonance (CMR) for quantification of 1) myocardial contractility by strain-encoded MR (SENC); 2) myocardial triglyceride content by proton magnetic resonance spectroscopy (1H-MRS); and 3) myocardial perfusion reserve during pharmacologic hyperemia. Age-matched healthy volunteers (n = 16) also underwent CMR to acquire normal values for myocardial strain and perfusion reserve. Results: Stress CMR procedures were successfully performed in all subjects, and no regional inducible perfusion defects were observed in type 2 diabetes mellitus patients. Diastolic strain rate and myocardial perfusion reserve were significantly impaired in patients with type 2 diabetes mellitus compared to control subjects (P < 0.001 for both). Interestingly, impaired diastolic function in type 2 diabetes mellitus was not associated with impaired myocardial perfusion reserve (r = 0.12, P = NS). Conversely a significant association was observed between diastolic dysfunction and myocardial triglyceride content (r = −0.71, P < 0.001), which proved to be independent of age, gender, diabetes duration, blood pressure, and fasting blood glucose. Conclusion: Myocardial steatosis may represent an early marker of diabetic heart disease, triggering subclinical myocardial dysfunction irrespective of myocardial perfusion reserve. J. Magn. Reson. Imaging 2012;35:804-811.