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Verfasst von:Korosoglou, Grigorios [VerfasserIn]   i
 Humpert, Per Magnus [VerfasserIn]   i
 Ahrens, Johannes [VerfasserIn]   i
 Oikonomou, Dimitrios [VerfasserIn]   i
 Gitsioudis, Gitsios [VerfasserIn]   i
 Buß, Sebastian Johannes [VerfasserIn]   i
 Steen, Henning [VerfasserIn]   i
 Bierhaus, Angelika [VerfasserIn]   i
 Nawroth, Peter Paul [VerfasserIn]   i
 Katus, Hugo [VerfasserIn]   i
Titel:Left ventricular diastolic function in type 2 diabetes mellitus is associated with myocardial triglyceride content but not with impaired myocardial perfusion reserve
Verf.angabe:Grigorios Korosoglou, Per M. Humpert, Johannes Ahrens, Dimitrios Oikonomou, Nael F. Osman, Gitsios Gitsioudis, Sebastian J. Buss, Henning Steen, Bernhardt Schnackenburg, Angelika Bierhaus, Peter P. Nawroth, and Hugo A. Katus
E-Jahr:2012
Jahr:June 26, 2012
Umfang:8 S.
Fussnoten:First published: 08 November 2011 ; Gesehen am 30.10.2018
Titel Quelle:Enthalten in: Journal of magnetic resonance imaging
Ort Quelle:New York, NY : Wiley-Liss, 1991
Jahr Quelle:2012
Band/Heft Quelle:35(2012), 4, Seite 804-811
ISSN Quelle:1522-2586
Abstract:Purpose: To study myocardial perfusion reserve and myocellular metabolic alterations indicated by triglyceride content as possible causes of diastolic dysfunction in patients with type 2 diabetes mellitus, preserved systolic function, and without clinically evident coronary artery disease. Materials and Methods: Patients with type 2 diabetes mellitus (n = 42) underwent cardiac magnetic resonance (CMR) for quantification of 1) myocardial contractility by strain-encoded MR (SENC); 2) myocardial triglyceride content by proton magnetic resonance spectroscopy (1H-MRS); and 3) myocardial perfusion reserve during pharmacologic hyperemia. Age-matched healthy volunteers (n = 16) also underwent CMR to acquire normal values for myocardial strain and perfusion reserve. Results: Stress CMR procedures were successfully performed in all subjects, and no regional inducible perfusion defects were observed in type 2 diabetes mellitus patients. Diastolic strain rate and myocardial perfusion reserve were significantly impaired in patients with type 2 diabetes mellitus compared to control subjects (P < 0.001 for both). Interestingly, impaired diastolic function in type 2 diabetes mellitus was not associated with impaired myocardial perfusion reserve (r = 0.12, P = NS). Conversely a significant association was observed between diastolic dysfunction and myocardial triglyceride content (r = −0.71, P < 0.001), which proved to be independent of age, gender, diabetes duration, blood pressure, and fasting blood glucose. Conclusion: Myocardial steatosis may represent an early marker of diabetic heart disease, triggering subclinical myocardial dysfunction irrespective of myocardial perfusion reserve. J. Magn. Reson. Imaging 2012;35:804-811.
DOI:doi:10.1002/jmri.22879
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1002/jmri.22879
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmri.22879
 DOI: https://doi.org/10.1002/jmri.22879
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:diastolic function
 myocardial triglyceride content
 strain-encoded MRI
 type 2 diabetes mellitus
 vascular function
K10plus-PPN:1582426511
Verknüpfungen:→ Zeitschrift

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