| Online-Ressource |
Verfasst von: | Korosoglou, Grigorios [VerfasserIn]  |
| Humpert, Per Magnus [VerfasserIn]  |
| Ahrens, Johannes [VerfasserIn]  |
| Oikonomou, Dimitrios [VerfasserIn]  |
| Gitsioudis, Gitsios [VerfasserIn]  |
| Buß, Sebastian Johannes [VerfasserIn]  |
| Steen, Henning [VerfasserIn]  |
| Bierhaus, Angelika [VerfasserIn]  |
| Nawroth, Peter Paul [VerfasserIn]  |
| Katus, Hugo [VerfasserIn]  |
Titel: | Left ventricular diastolic function in type 2 diabetes mellitus is associated with myocardial triglyceride content but not with impaired myocardial perfusion reserve |
Verf.angabe: | Grigorios Korosoglou, Per M. Humpert, Johannes Ahrens, Dimitrios Oikonomou, Nael F. Osman, Gitsios Gitsioudis, Sebastian J. Buss, Henning Steen, Bernhardt Schnackenburg, Angelika Bierhaus, Peter P. Nawroth, and Hugo A. Katus |
E-Jahr: | 2012 |
Jahr: | June 26, 2012 |
Umfang: | 8 S. |
Fussnoten: | First published: 08 November 2011 ; Gesehen am 30.10.2018 |
Titel Quelle: | Enthalten in: Journal of magnetic resonance imaging |
Ort Quelle: | New York, NY : Wiley-Liss, 1991 |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 35(2012), 4, Seite 804-811 |
ISSN Quelle: | 1522-2586 |
Abstract: | Purpose: To study myocardial perfusion reserve and myocellular metabolic alterations indicated by triglyceride content as possible causes of diastolic dysfunction in patients with type 2 diabetes mellitus, preserved systolic function, and without clinically evident coronary artery disease. Materials and Methods: Patients with type 2 diabetes mellitus (n = 42) underwent cardiac magnetic resonance (CMR) for quantification of 1) myocardial contractility by strain-encoded MR (SENC); 2) myocardial triglyceride content by proton magnetic resonance spectroscopy (1H-MRS); and 3) myocardial perfusion reserve during pharmacologic hyperemia. Age-matched healthy volunteers (n = 16) also underwent CMR to acquire normal values for myocardial strain and perfusion reserve. Results: Stress CMR procedures were successfully performed in all subjects, and no regional inducible perfusion defects were observed in type 2 diabetes mellitus patients. Diastolic strain rate and myocardial perfusion reserve were significantly impaired in patients with type 2 diabetes mellitus compared to control subjects (P < 0.001 for both). Interestingly, impaired diastolic function in type 2 diabetes mellitus was not associated with impaired myocardial perfusion reserve (r = 0.12, P = NS). Conversely a significant association was observed between diastolic dysfunction and myocardial triglyceride content (r = −0.71, P < 0.001), which proved to be independent of age, gender, diabetes duration, blood pressure, and fasting blood glucose. Conclusion: Myocardial steatosis may represent an early marker of diabetic heart disease, triggering subclinical myocardial dysfunction irrespective of myocardial perfusion reserve. J. Magn. Reson. Imaging 2012;35:804-811. |
DOI: | doi:10.1002/jmri.22879 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: http://dx.doi.org/10.1002/jmri.22879 |
| Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmri.22879 |
| DOI: https://doi.org/10.1002/jmri.22879 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | diastolic function |
| myocardial triglyceride content |
| strain-encoded MRI |
| type 2 diabetes mellitus |
| vascular function |
K10plus-PPN: | 1582426511 |
Verknüpfungen: | → Zeitschrift |
Left ventricular diastolic function in type 2 diabetes mellitus is associated with myocardial triglyceride content but not with impaired myocardial perfusion reserve / Korosoglou, Grigorios [VerfasserIn]; June 26, 2012 (Online-Ressource)