Role of KCNQ channels in skeletal muscle arteries and periadventitial vascular dysfunction

• Verfasst von: Zavaritskaya, Olga [VerfasserIn]
• Verfasst von: Gloe, Torsten [VerfasserIn]
• Verfasst von: Devermann, Lena [VerfasserIn]
• Verfasst von: Schubert, Rudolf [VerfasserIn]
• Titel: Role of KCNQ channels in skeletal muscle arteries and periadventitial vascular dysfunction
• Verf.angabe: Olga Zavaritskaya, Nadezda Zhuravleva, Johanna Schleifenbaum, Torsten Gloe, Lena Devermann, Reinhart Kluge, Mitko Mladenov, Manfred Frey, Hristo Gagov, Gabor Fésüs, Maik Gollasch, Rudolf Schubert
• Jahr: 2013
• Jahr des Originals: 2012
• Umfang: 9 S.
• Fussnoten: Originally published 26 Nov 2012 ; Gesehen am 30.10.2018
• Titel Quelle: Enthalten in: Hypertension
• Ort Quelle: Baltimore, Md. : Williams & Wilkins, 1979
• Jahr Quelle: 2013
• Band/Heft Quelle: 61(2013), 1, Seite 151-159
• ISSN Quelle: 1524-4563
• DOI: doi:10.1161/HYPERTENSIONAHA.112.197566
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1582435790

Abstract

KCNQ channels have been identified in arterial smooth muscle. However, their role in vasoregulation and chronic vascular diseases remains elusive. We tested the hypothesis that KCNQ channels contribute to periadventitial vasoregulation in peripheral skeletal muscle arteries by perivascular adipose tissue and that they represent novel targets to rescue periadventitial vascular dysfunction. Two models, spontaneously hypertensive rats and New Zealand obese mice, were studied using quantitative polymerase chain reaction, the patch-clamp technique, membrane potential measurements, myography of isolated vessels, and blood pressure telemetry. In rat Gracilis muscle arteries, anticontractile effects of perivascular fat were inhibited by the KCNQ channel blockers XE991 and linopirdine but not by other selective K+ channel inhibitors. Accordingly, XE991 and linopirdine blocked noninactivating K+ currents in freshly isolated Gracilis artery smooth muscle cells. mRNAs of several KCNQ channel subtypes were detected in...