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Verfasst von:Mihai, Carina [VerfasserIn]   i
 Grünig, Ekkehard [VerfasserIn]   i
Titel:Factors associated with disease progression in early-diagnosed pulmonary arterial hypertension associated with systemic sclerosis
Titelzusatz:longitudinal data from the DETECT cohort
Verf.angabe:Carina Mihai, Milos Antic, Rucsandra Dobrota, Diana Bonderman, Harbajan Chadha-Boreham, John Gerry Coghlan, Christopher P. Denton, Martin Doelberg, Ekkehard Grünig, Dinesh Khanna, Vallerie V. McLaughlin, Ulf Müller-Ladner, Janet E. Pope, Daniel M. Rosenberg, James R. Seibold, Madelon C. Vonk, Oliver Distler
Jahr:2018
Umfang:5 S.
Fussnoten:Published online first 23 October 2017 ; Gesehen am 31.10.2018
Titel Quelle:Enthalten in: Annals of the rheumatic diseases
Ort Quelle:London : BMJ Publ. Group, 1939
Jahr Quelle:2018
Band/Heft Quelle:77(2018), 1, Seite 128-132
ISSN Quelle:1468-2060
Abstract:Objective Pulmonary arterial hypertension (PAH) is a severe complication of systemic sclerosis (SSc). In this longitudinal study, we aimed to identify factors associated with an unfavourable outcome in patients with SSc with early PAH (SSc-PAH) from the DETECT cohort. Methods Patients with SSc-PAH enrolled in DETECT were observed for up to 3 years. Associations between cross-sectional variables and disease progression (defined as the occurrence of any of the following events: WHO Functional Class worsening, combination therapy for PAH, hospitalisation or death) were analysed by univariable logistic regression. Results Of 57 patients with PAH (median observation time 12.6 months), 25 (43.9%) had disease progression. The following factors (OR (95% CI)) were associated with disease progression: male gender (4.1 (1.2 to 14.1)), high forced vital capacity % predicted/carbon monoxide lung diffusion capacity (DLCO)% predicted ratio (3.6 (1.2 to 10.7)), high Borg Dyspnoea Index (1.7 (1.1 to 2.6)) and low DLCO% predicted (non-linear relationship). Conclusion More than 40% of early-diagnosed patients with SSc-PAH had disease progression during a short follow-up time, with male gender, functional capacity and pulmonary function tests at PAH diagnosis being associated with progression. This suggests that even mild PAH should be considered a high-risk complication of SSc.
DOI:doi:10.1136/annrheumdis-2017-211480
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1136/annrheumdis-2017-211480
 Volltext: https://ard.bmj.com/content/77/1/128
 DOI: https://doi.org/10.1136/annrheumdis-2017-211480
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:cardiovascular disease
 epidemiology
 systemic sclerosis
K10plus-PPN:1582448167
Verknüpfungen:→ Zeitschrift

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