| Online-Ressource |
Verfasst von: | Mihai, Carina [VerfasserIn]  |
| Grünig, Ekkehard [VerfasserIn]  |
Titel: | Factors associated with disease progression in early-diagnosed pulmonary arterial hypertension associated with systemic sclerosis |
Titelzusatz: | longitudinal data from the DETECT cohort |
Verf.angabe: | Carina Mihai, Milos Antic, Rucsandra Dobrota, Diana Bonderman, Harbajan Chadha-Boreham, John Gerry Coghlan, Christopher P. Denton, Martin Doelberg, Ekkehard Grünig, Dinesh Khanna, Vallerie V. McLaughlin, Ulf Müller-Ladner, Janet E. Pope, Daniel M. Rosenberg, James R. Seibold, Madelon C. Vonk, Oliver Distler |
Jahr: | 2018 |
Umfang: | 5 S. |
Fussnoten: | Published online first 23 October 2017 ; Gesehen am 31.10.2018 |
Titel Quelle: | Enthalten in: Annals of the rheumatic diseases |
Ort Quelle: | London : BMJ Publ. Group, 1939 |
Jahr Quelle: | 2018 |
Band/Heft Quelle: | 77(2018), 1, Seite 128-132 |
ISSN Quelle: | 1468-2060 |
Abstract: | Objective Pulmonary arterial hypertension (PAH) is a severe complication of systemic sclerosis (SSc). In this longitudinal study, we aimed to identify factors associated with an unfavourable outcome in patients with SSc with early PAH (SSc-PAH) from the DETECT cohort. Methods Patients with SSc-PAH enrolled in DETECT were observed for up to 3 years. Associations between cross-sectional variables and disease progression (defined as the occurrence of any of the following events: WHO Functional Class worsening, combination therapy for PAH, hospitalisation or death) were analysed by univariable logistic regression. Results Of 57 patients with PAH (median observation time 12.6 months), 25 (43.9%) had disease progression. The following factors (OR (95% CI)) were associated with disease progression: male gender (4.1 (1.2 to 14.1)), high forced vital capacity % predicted/carbon monoxide lung diffusion capacity (DLCO)% predicted ratio (3.6 (1.2 to 10.7)), high Borg Dyspnoea Index (1.7 (1.1 to 2.6)) and low DLCO% predicted (non-linear relationship). Conclusion More than 40% of early-diagnosed patients with SSc-PAH had disease progression during a short follow-up time, with male gender, functional capacity and pulmonary function tests at PAH diagnosis being associated with progression. This suggests that even mild PAH should be considered a high-risk complication of SSc. |
DOI: | doi:10.1136/annrheumdis-2017-211480 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: http://dx.doi.org/10.1136/annrheumdis-2017-211480 |
| Volltext: https://ard.bmj.com/content/77/1/128 |
| DOI: https://doi.org/10.1136/annrheumdis-2017-211480 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | cardiovascular disease |
| epidemiology |
| systemic sclerosis |
K10plus-PPN: | 1582448167 |
Verknüpfungen: | → Zeitschrift |
Factors associated with disease progression in early-diagnosed pulmonary arterial hypertension associated with systemic sclerosis / Mihai, Carina [VerfasserIn]; 2018 (Online-Ressource)