Impact of early initiation versus national standard of care of antiretroviral therapy in Swaziland’s public sector health system

• Verfasst von: Walsh, Fiona J. [VerfasserIn]
• Verfasst von: Bärnighausen, Till [VerfasserIn]
• Verfasst von: Delva, Wim [VerfasserIn]
• Titel: Impact of early initiation versus national standard of care of antiretroviral therapy in Swaziland’s public sector health system
• Titelzusatz: study protocol for a stepped-wedge randomized trial
• Verf.angabe: Fiona J. Walsh, Till Bärnighausen, Wim Delva, Yvette Fleming, Gavin Khumalo, Charlotte L. Lejeune, Sikhathele Mazibuko, Charmaine Khudzie Mlambo, Ria Reis, Donna Spiegelman, Mandisa Zwane, Velephi Okello
• E-Jahr: 2017
• Jahr: 18 August 2017
• Umfang: 10 S.
• Fussnoten: Gesehen am 31.10.2018
• Titel Quelle: Enthalten in: Trials
• Ort Quelle: London : BioMed Central, 2000
• Jahr Quelle: 2017
• Band/Heft Quelle: 18(2017), Artikel-ID 383, Seite 1-10
• ISSN Quelle: 1468-6694
• ISSN Quelle: 1745-6215
• DOI: doi:10.1186/s13063-017-2128-8
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1582452210

Abstract

There is robust clinical evidence to support offering early access to antiretroviral treatment (ART) to all HIV-positive individuals, irrespective of disease stage, to both improve patient health outcomes and reduce HIV incidence. However, as the global treatment guidelines shift to meet this evidence, it is still largely unknown if early access to ART for all (also referred to as “treatment as prevention” or “universal test and treat”) is a feasible intervention in the resource-limited countries where this approach could have the biggest impact on the course of the HIV epidemics. The MaxART Early Access to ART for All (EAAA) implementation study was designed to determine the feasibility, acceptability, clinical outcomes, affordability, and scalability of offering early antiretroviral treatment to all HIV-positive individuals in Swaziland’s public sector health system.