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Verfasst von:Kynast-Wolf, Gisela [VerfasserIn]   i
 Wakilzadeh, Wieda [VerfasserIn]   i
 Schnitzler, Paul [VerfasserIn]   i
 Becher, Heiko [VerfasserIn]   i
 Müller, Olaf [VerfasserIn]   i
Titel:ITN protection, MSP1 antibody levels and malaria episodes in young children of rural Burkina Faso
Verf.angabe:Gisela Kynast-Wolf, Wieda Wakilzadeh, Boubacar Coulibaly, Paul Schnitzler, Corneille Traoré, Heiko Becher, Olaf Müller
E-Jahr:2012
Jahr:August 2012
Umfang:6 S.
Fussnoten:Gesehen am 31.10.2018
Titel Quelle:Enthalten in: Acta tropica
Ort Quelle:Amsterdam [u.a.] : Elsevier, 1989
Jahr Quelle:2012
Band/Heft Quelle:123(2012), 2, Seite 117-122
ISSN Quelle:1873-6254
Abstract:Malaria blood-stage vaccines are in an early phase of clinical development with MSP1 being a major antigen candidate. There are limited data on the protective efficacy of antibodies against subunits of MSP1 in the malaria endemic areas of sub-Saharan Africa. This prospective cohort study was nested into a large insecticide-treated mosquito net (ITN) trial during which neonates were individually randomised to ITN protection from birth vs. protection from month six onwards in rural Burkina Faso. A sub sample of 120 children from three villages was followed for 10 months with six measurements of MSP142 antibodies (ELISA based on recombinant 42kDa fragment) and daily assessment of malaria episodes. Time to the next malaria episode was determined in relation to MSP142 antibody titres. MSP142 antibody titres were dependent on age, season, ITN-group, number of previous malaria episodes and parasitaemia. There were no significant differences in time until the next malaria episode in children with low compared to children with high MSP142 antibody titres at any point in time (101 vs. 97 days in May, p=0.6; 58 vs. 84 days in September, p=0.3; 144 vs. 161 days in March, p=0.5). The findings of this study support the short-lived nature of the humoral immune response in infants of malaria endemic areas. The study provides no evidence for antibodies against a subunit of MSP1 being protective against new malaria episodes in infants.
DOI:doi:10.1016/j.actatropica.2012.04.010
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1016/j.actatropica.2012.04.010
 Volltext: http://www.sciencedirect.com/science/article/pii/S0001706X12001878
 DOI: https://doi.org/10.1016/j.actatropica.2012.04.010
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Africa
 Burkina Faso
 Infants
 Insecticide-treated mosquito nets
 Malaria
 MSP1 antibodies
 Season
K10plus-PPN:1582453276
Verknüpfungen:→ Zeitschrift

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