Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Knoefler, Daniela [VerfasserIn]  |
| Koniczek, Martin [VerfasserIn]  |
Titel: | Quantitative in vivo redox sensors uncover oxidative stress as an early event in life |
Verf.angabe: | Daniela Knoefler, Maike Thamsen, Martin Koniczek, Nicholas J. Niemuth, Ann-Kristin Diederich and Ursula Jakob |
E-Jahr: | 2012 |
Jahr: | 14 September 2012 |
Umfang: | 10 S. |
Fussnoten: | Available online 19 July 2012 ; Gesehen am 31.10.2018 |
Titel Quelle: | Enthalten in: Molecular cell |
Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1997 |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 47(2012), 5, Seite 767-776 |
ISSN Quelle: | 1097-4164 |
Abstract: | Summary Obstacles in elucidating the role of oxidative stress in aging include difficulties in (1) tracking in vivo oxidants, in (2) identifying affected proteins, and in (3) correlating changes in oxidant levels with life span. Here, we used quantitative redox proteomics to determine the onset and the cellular targets of oxidative stress during Caenorhabditis elegans’ life span. In parallel, we used genetically encoded sensor proteins to determine peroxide levels in live animals in real time. We discovered that C. elegans encounters significant levels of oxidants as early as during larval development. Oxidant levels drop rapidly as animals mature, and reducing conditions prevail throughout the reproductive age, after which age-accompanied protein oxidation sets in. Long-lived daf-2 mutants transition faster to reducing conditions, whereas short-lived daf-16 mutants retain higher oxidant levels throughout their mature life. These results suggest that animals with improved capacity to recover from early oxidative stress have significant advantages later in life. |
DOI: | doi:10.1016/j.molcel.2012.06.016 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.molcel.2012.06.016 |
| Volltext: http://www.sciencedirect.com/science/article/pii/S1097276512005412 |
| DOI: https://doi.org/10.1016/j.molcel.2012.06.016 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1582457425 |
Verknüpfungen: | → Zeitschrift |
Quantitative in vivo redox sensors uncover oxidative stress as an early event in life / Knoefler, Daniela [VerfasserIn]; 14 September 2012 (Online-Ressource)
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