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Verfasst von:Ilander, Mette Matilda [VerfasserIn]   i
 Saußele, Susanne [VerfasserIn]   i
Titel:Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia
Verf.angabe:M. Ilander, U. Olsson-Strömberg, H. Schlums, J. Guilhot, O. Brück, H. Lähteenmäki, T. Kasanen, P. Koskenvesa, S. Söderlund, M. Höglund, B. Markevärn, A. Själander, K. Lotfi, A. Dreimane, A. Lübking, E. Holm, M. Björeman, S. Lehmann, L. Stenke, L. Ohm, T. Gedde-Dahl, W. Majeed, H. Ehrencrona, S. Koskela, S. Saussele, F.-X. Mahon, K. Porkka, H. Hjorth-Hansen, Y. T. Bryceson, J. Richter, S. Mustjoki
Jahr:2017
Umfang:9 S.
Fussnoten:Published: 28 November 2016 ; Gesehen am 05.11.2018
Titel Quelle:Enthalten in: Leukemia
Ort Quelle:London : Springer Nature, 1997
Jahr Quelle:2017
Band/Heft Quelle:31(2017), 5, Seite 1108-1116
ISSN Quelle:1476-5551
Abstract:Recent studies suggest that a proportion of chronic myeloid leukemia (CML) patients in deep molecular remission can discontinue the tyrosine kinase inhibitor (TKI) treatment without disease relapse. In this multi-center, prospective clinical trial (EURO-SKI, NCT01596114) we analyzed the function and phenotype of T and NK cells and their relation to successful TKI cessation. Lymphocyte subclasses were measured from 100 imatinib-treated patients at baseline and 1 month after the discontinuation, and functional characterization of NK and T cells was done from 45 patients. The proportion of NK cells was associated with the molecular relapse-free survival as patients with higher than median NK-cell percentage at the time of drug discontinuation had better probability to stay in remission. Similar association was not found with T or B cells or their subsets. In non-relapsing patients the NK-cell phenotype was mature, whereas patients with more naïve CD56bright NK cells had decreased relapse-free survival. In addition, the TNF-α/IFN-γ cytokine secretion by NK cells correlated with the successful drug discontinuation. Our results highlight the role of NK cells in sustaining remission and strengthen the status of CML as an immunogenic tumor warranting novel clinical trials with immunomodulating agents.
DOI:doi:10.1038/leu.2016.360
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: http://dx.doi.org/10.1038/leu.2016.360
 kostenfrei: Volltext: https://www.nature.com/articles/leu2016360
 DOI: https://doi.org/10.1038/leu.2016.360
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1582534322
Verknüpfungen:→ Zeitschrift

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