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Status: Bibliographieeintrag

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Verfasst von:Acosta, Eliana G. [VerfasserIn]   i
 Castilla, Viviana [VerfasserIn]   i
 Damonte, Elsa B. [VerfasserIn]   i
Titel:Differential requirements in endocytic trafficking for penetration of dengue virus
Verf.angabe:Eliana G. Acosta, Viviana Castilla, Elsa B. Damonte
E-Jahr:2012
Jahr:September 7, 2012
Umfang:13 S.
Fussnoten:Gesehen am 05.12.2018
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2012
Band/Heft Quelle:7(2012), 9, Artikel-ID e44835
ISSN Quelle:1932-6203
Abstract:The entry of DENV into the host cell appears to be a very complex process which has been started to be studied in detail. In this report, the route of functional intracellular trafficking after endocytic uptake of dengue virus serotype 1 (DENV-1) strain HW, DENV-2 strain NGC and DENV-2 strain 16681 into Vero cells was studied by using a susceptibility to ammonium chloride assay, dominant negative mutants of several members of the family of cellular Rab GTPases that participate in regulation of transport through endosome vesicles and immunofluorescence colocalization. Together, the results presented demonstrate that in spite of the different internalization route among viral serotypes in Vero cells and regardless of the viral strain, DENV particles are first transported to early endosomes in a Rab5-dependent manner. Then a Rab7-dependent pathway guides DENV-2 16681 to late endosomes, whereas a yet unknown sorting event controls the transport of DENV-2 NGC, and most probably DENV-1 HW, to the perinuclear recycling compartments where fusion membrane would take place releasing nucleocapsid into the cytoplasm. Besides the demonstration of a different intracellular trafficking for two DENV-2 strains that shared the initial clathrin-independent internalization route, these studies proved for the first time the involvement of the slow recycling pathway for DENV-2 productive infection.
DOI:doi:10.1371/journal.pone.0044835
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1371/journal.pone.0044835
 Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044835
 DOI: https://doi.org/10.1371/journal.pone.0044835
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Chlorides
 Cytoplasm
 Endosomes
 Immunofluorescence
 Membrane fusion
 Vero cells
 Vesicles
 Virions
K10plus-PPN:1582552827
Verknüpfungen:→ Zeitschrift

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