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Verfasst von:Kuon, Ruben-Jeremias [VerfasserIn]   i
 Vomstein, Kilian [VerfasserIn]   i
 Weber, M. [VerfasserIn]   i
 Müller, F. [VerfasserIn]   i
 Seitz, Christoph [VerfasserIn]   i
 Wallwiener, Stephanie [VerfasserIn]   i
 Strowitzki, Thomas [VerfasserIn]   i
 Schleußner, Ekkehard [VerfasserIn]   i
 Markert, Udo R. [VerfasserIn]   i
 Daniel, Volker [VerfasserIn]   i
 Toth, Bettina [VerfasserIn]   i
Titel:The “killer cell story” in recurrent miscarriage
Titelzusatz:association between activated peripheral lymphocytes and uterine natural killer cells
Verf.angabe:R.J. Kuon, K. Vomstein, M. Weber, F. Müller, C. Seitz, S. Wallwiener, T. Strowitzki, E. Schleussner, U.R. Markert, V. Daniel, B. Toth
Jahr:2017
Umfang:6 S.
Fussnoten:Available online 6 November 2016 ; Gesehen am 05.11.2018
Titel Quelle:Enthalten in: Journal of reproductive immunology
Ort Quelle:Oxford : Oxford University Press, 1979
Jahr Quelle:2017
Band/Heft Quelle:119(2017), Seite 9-14
ISSN Quelle:1872-7603
Abstract:Peripheral and uterine NK cells (pNK, uNK) can be distinguished according to their receptor expression. Recent studies indicate an association of elevated pNK and uNK with recurrent miscarriage (RM). This study aimed to analyze pNK and uNK in patients with RM and healthy controls. Out of n=590 RM patients screened according to a standard diagnostic protocol, n=268 couples with ≥3 consecutive RM were identified. Subgroups consisted of n=151 primary RM (pRM), n=85 secondary RM (sRM), n=32 tertiary RM (tRM) and n=42 healthy controls. Finally, n=147 idiopathic RM (iRM) and n=121 non-iRM patients were identified. Peripheral blood levels of CD45+CD3-CD56+CD16+ NK cells were determined in non-pregnant patients and controls in the mid-luteal phase by FACS. In n=129 RM patients a uterine biopsy was taken to evaluate CD56+ NK cells by immunohistochemistry. PRM showed higher absolute pNK than sRM (median/μl (Q1;Q3): 234 (147;306) vs 176 (128;245), p=0.02). Further a trend towards higher pNK percentages in pRM was detected. UNK numbers did not differ between RM subgroups and did not correlate with pNK. However, the rate of highly elevated uNK was increased in iRM compared to non-iRM patients (p=0.04). Further, higher numbers of CD45+CD3-DR+ (p<0.01) and CD45+CD3+CD8+DR+ (p=0.04) peripheral lymphocytes were associated with higher uNK numbers. In conclusion, elevated pNK were present in pRM patients. Although pNK and uNK numbers did not correlate, the association between high CD45+CD3-DR+ and CD45+CD3+CD8+DR+ peripheral lymphocytes and uNK might indicate that activated NK, B and T cells provide cytokines for the differentiation of uNK.
DOI:doi:10.1016/j.jri.2016.11.002
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.jri.2016.11.002
 Volltext: http://www.sciencedirect.com/science/article/pii/S0165037816304107
 DOI: https://doi.org/10.1016/j.jri.2016.11.002
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Endometrium
 Immune status
 Natural killer cells
 Recurrent miscarriage
K10plus-PPN:1582567174
Verknüpfungen:→ Zeitschrift

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