Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Pierau, Mandy [VerfasserIn]  |
| Marx, Alexander [VerfasserIn]  |
Titel: | Constitutive Akt1 signals attenuate B-cell receptor signaling and proliferation, but enhance B-cell migration and effector function |
Verf.angabe: | Mandy Pierau, Shin-Young Na, Narasimhulu Simma, Theresa Lowinus, Alexander Marx, Burkhart Schraven and Ursula H. Bommhardt |
E-Jahr: | 2012 |
Jahr: | 18 December 2012 |
Umfang: | 13 S. |
Fussnoten: | Gesehen am 05.11.2018 |
Titel Quelle: | Enthalten in: European journal of immunology |
Ort Quelle: | Weinheim : Wiley-VCH, 1971 |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 42(2012), 12, Seite 3381-3393 |
ISSN Quelle: | 1521-4141 |
Abstract: | Ligation of the BCR induces a complex signaling network that involves activation of Akt, a family of serine/threonine protein kinases associated with B-cell development, proliferation, and tumor formation. Here, we analyzed the effect of enhanced Akt1 signals on B-cell maturation and function. Unexpectedly, we found that peripheral B cells overexpressing Akt1 were less responsive to BCR stimuli. This correlated with a decrease in Ca2+-mobilization and proliferation, in an impaired activation of Erk1/2 and mammalian target of rapamycin (mTOR) kinases and poor mobilization of NFATc1 and NF-κB/p65 factors. In contrast, activation of STAT5 and migration of B cells toward the chemokine SDF1α was found to be enhanced. Akt1 Tg mice showed an altered maturation of peritoneal and splenic B1 B cells and an enhanced production of IgG1 and IgG3 upon immunization with the T-cell independent Ag TNP-Ficoll. Furthermore, mice homo-zygous for Tg Akt1 showed a severe block in the maturation of B-cell precursors in BM and a strong enrichment of plasma cells in spleen. Altogether, our data reveal that enhanced Akt1 signals modify BCR signaling strength and, thereby, B-cell development and effector function. |
DOI: | doi:10.1002/eji.201242397 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1002/eji.201242397 |
| Volltext: https://www.onlinelibrary.wiley.com/doi/abs/10.1002/eji.201242397 |
| DOI: https://doi.org/10.1002/eji.201242397 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | B cell |
| NFAT |
| PKB/Akt |
| SDF1α |
| STAT5 |
K10plus-PPN: | 1582583803 |
Verknüpfungen: | → Zeitschrift |
Constitutive Akt1 signals attenuate B-cell receptor signaling and proliferation, but enhance B-cell migration and effector function / Pierau, Mandy [VerfasserIn]; 18 December 2012 (Online-Ressource)
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