| |  Online-Ressource |
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| Verfasst von: | Smida, Jan [VerfasserIn]  |
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| | Xu, Hongen [VerfasserIn] |
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| | Zhang, Yanping [VerfasserIn] |
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| | Baumhoer, Daniel [VerfasserIn] |
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| | Ribi, Sebastian [VerfasserIn] |
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| | Kovac, Michal [VerfasserIn] |
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| | Teichert- von Lüttichau, Irene [VerfasserIn] |
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| | Bielack, Stefan [VerfasserIn] |
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| | O'Leary, Valerie B. [VerfasserIn] |
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| | Leib-Mösch, Christine [VerfasserIn] |
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| | Frishman, Dmitij [VerfasserIn] |
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| | Nathrath, Michaela [VerfasserIn] |
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| Titel: | Genome-wide analysis of somatic copy number alterations and chromosomal breakages in osteosarcoma |
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| Verf.angabe: | Jan Smida, Hongen Xu, Yanping Zhang, Daniel Baumhoer, Sebastian Ribi, Michal Kovac, Irene von Luettichau, Stefan Bielack, Valerie B. O'Leary, Christine Leib‐Mösch, Dmitrij Frishman and Michaela Nathrath |
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| E-Jahr: | 2017 |
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| Jahr: | 11 May 2017 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 05.11.2018 |
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| Titel Quelle: | Enthalten in: International journal of cancer |
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| Ort Quelle: | Bognor Regis : Wiley-Liss, 1966 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 141(2017), 4, Seite 816-828 |
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| ISSN Quelle: | 1097-0215 |
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| Abstract: | Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. It is characterized by highly complex karyotypes with structural and numerical chromosomal alterations. The observed OS-specific characteristics in localization and frequencies of chromosomal breakages strongly implicate a specific set of responsible driver genes or a specific mechanism of fragility induction. In this study, a comprehensive assessment of somatic copy number alterations (SCNAs) was performed in 160 OS samples using whole-genome CytoScan High Density arrays (Affymetrix, Santa Clara, CA). Genes or regions frequently targeted by SCNAs were identified. Breakage analysis revealed OS specific unstable regions in which well-known OS tumor suppressor genes, including TP53, RB1, WWOX, DLG2 and LSAMP are located. Certain genomic features, such as transposable elements and non-B DNA-forming motifs were found to be significantly enriched in the vicinity of chromosomal breakage sites. A complex breakage pattern - chromothripsis - has been suggested as a widespread phenomenon in OS. It was further demonstrated that hyperploidy and in particular chromothripsis were strongly correlated with OS patient clinical outcome. The revealed OS-specific fragility pattern provides novel clues for understanding the biology of OS. |
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| DOI: | doi:10.1002/ijc.30778 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1002/ijc.30778 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.30778 |
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| | DOI: https://doi.org/10.1002/ijc.30778 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | chromosomal breakage pattern |
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| | chromothripsis |
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| | driver genes |
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| | osteosarcoma |
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| | SCNAs |
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| K10plus-PPN: | 1582585776 |
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| Verknüpfungen: | → Zeitschrift |
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Genome-wide analysis of somatic copy number alterations and chromosomal breakages in osteosarcoma / Smida, Jan [VerfasserIn]; 11 May 2017 (Online-Ressource)
