Survival after resection of appendiceal carcinoma by hemicolectomy and less radical than hemicolectomy

• Verfasst von: Elias, Hanna [VerfasserIn]
• Verfasst von: Galata, Christian [VerfasserIn]
• Verfasst von: Post, Stefan [VerfasserIn]
• Verfasst von: Marti, Lukas [VerfasserIn]
• Titel: Survival after resection of appendiceal carcinoma by hemicolectomy and less radical than hemicolectomy
• Titelzusatz: a population-based propensity score matched analysis
• Verf.angabe: H. Elias, C. Galata, R. Warschkow, B.M. Schmied, T. Steffen, S. Post and L. Marti
• E-Jahr: 2017
• Jahr: October 2017
• Umfang: 12 S.
• Fussnoten: Gesehen am 06.11.2018
• Titel Quelle: Enthalten in: Colorectal disease
• Ort Quelle: Oxford [u.a.] : Wiley-Blackwell, 1999
• Jahr Quelle: 2017
• Band/Heft Quelle: 19(2017), 10, Seite 895-906
• ISSN Quelle: 1463-1318
• DOI: doi:10.1111/codi.13746
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: adenocarcinoma
• Sach-SW: Appendix
• Sach-SW: prognostic factors
• Sach-SW: right hemicolectomy
• Sach-SW: surgical technique
• K10plus-PPN: 1582633657

Abstract

Aim The operative treatment for non-metastatic appendiceal carcinoma is controversial despite the recommendation of right hemicolectomy (RH) by many researchers. The aim of this population-based study was to compare outcomes after RH and less radical resection than right hemicolectomy (LRH). Method A total of 1144 patients who underwent resection with additional lymphadenectomy of Stages I-III appendiceal carcinoma from 2004 to 2012 were identified in the Surveillance, Epidemiology and End Results database. Overall survival (OS) and cancer-specific survival (CSS) after RH and LRH were assessed by unadjusted and risk-adjusted Cox regression analysis and by propensity score matched analysis. Results A total of 855 (74.7%) patients underwent RH and 289 (25.3%) underwent LRH. In an unadjusted analysis, survival after LRH and RH did not differ in OS [hazard ratio (HR) 0.95, 95% CI 0.71-1.26, P = 0.707] and CSS (HR 0.95, 95% CI 0.69-1.32, P = 0.762). The 5-year OS and CSS in patients who underwent RH were 71.6% (95% CI 67.8-75.6%) and 76.4% (95% CI 72.8-80.3) compared with 73.8% (95% CI 67.9-80.2) and 78.7% (95% CI 73.2-84.7) in patients with LRH, respectively. No relevant difference in survival between LRH and RH could be observed in a multivariable analysis (OS, HR 0.90, 95% CI 0.65-1.25, P = 0.493; CSS, HR 0.87, 95% CI 0.60-1.26, P = 0.420) and after propensity score adjusted analysis (OS, HR 0.87, 95% CI 0.62-1.22, P = 0.442; CSS, HR 0.97, 95% CI 0.67-1.40, P = 0.883). Conclusions In this retrospective analysis, survival after RH for non-metastatic appendiceal carcinoma was not statistically significantly superior to LRH. Hence, LRH with lymphadenectomy might be sufficient for treatment of non-metastatic appendiceal carcinoma.