Evidence for the involvement of ZNF804A in cognitive processes of relevance to reading and spelling

• Verfasst von: Becker, Jessica [VerfasserIn]
• Verfasst von: Brandeis, Daniel [VerfasserIn]
• Titel: Evidence for the involvement of ZNF804A in cognitive processes of relevance to reading and spelling
• Verf.angabe: J. Becker, D. Czamara, P. Hoffmann, K. Landerl, L. Blomert, D. Brandeis, A. Vaessen, U. Maurer, K. Moll, K.U. Ludwig, B. Müller-Myhsok, M.M. Nöthen, G. Schulte-Körne and J. Schumacher
• E-Jahr: 2012
• Jahr: 10 July 2012
• Umfang: 3 S.
• Fussnoten: Gesehen am 07.11.2018
• Titel Quelle: Enthalten in: Translational Psychiatry
• Ort Quelle: London : Nature Publishing Group, 2011
• Jahr Quelle: 2012
• Band/Heft Quelle: 2(2012), Artikel-ID e136
• ISSN Quelle: 2158-3188
• DOI: doi:10.1038/tp.2012.62
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1582679703

Abstract

Previous studies have shown that individuals with schizophrenia and dyslexia display common neurocognitive abnormalities. The aim of the present study was to determine whether known schizophrenia-risk genes contribute to dyslexia risk or to disease-relevant cognitive functions. For this purpose, we genotyped the schizophrenia-associated risk variants within zinc-finger protein 804A (ZNF804A), transcription-factor 4 and neurogranin in a large dyslexia case-control sample. We tested all variants for association with dyslexia (927 cases, 1096 controls), and with eight language-relevant cognitive processes (1552 individuals). We observed six significant associations between language-relevant traits and the ZNF804A-variant rs1344706. Interestingly, the ZNF804A schizophrenia risk variant was associated with a better cognitive performance in our data set. This finding might be consistent with a previously reported ZNF804A association in schizophrenia, in which patients carrying the schizophrenia-risk allele at rs1344706 showed a better performance in two memory tests. In conclusion, the present study provides evidence that ZNF804A might have a role in cognitive traits of relevance to reading and spelling, and underlines the phenotypic complexity that might be associated with ZNF804A.