Metal complex derivatives of peptide nucleic acids (PNA)

• Verfasst von: Krämer, Roland [VerfasserIn]
• Verfasst von: Mokhir, Andriy [VerfasserIn]
• Titel: Metal complex derivatives of peptide nucleic acids (PNA)
• Verf.angabe: Roland Krämer, Andriy Mokhir
• Jahr: 2012
• Umfang: 22 S.
• Fussnoten: First online: 30 September 2011 ; Gesehen am 08.11.2018
• Titel Quelle: Enthalten in: Interplay between metal ions and nucleic acids
• Ort Quelle: Dordrecht : Springer Netherlands, 2012
• Jahr Quelle: 2012
• Band/Heft Quelle: (2012), Seite 319-340
• ISBN Quelle: 978-94-007-2172-2
• DOI: doi:10.1007/978-94-007-2172-2_12
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: cellular uptake
• Sach-SW: labels
• Sach-SW: metal complexes
• Sach-SW: nucleic acid detection
• Sach-SW: peptide nucleic acids
• K10plus-PPN: 1582720517

Abstract

Peptide nucleic acid (PNA) is a non-cyclic pseudopeptide-nucleic acid structural mimic with promising applications within diagnostics and drug discovery. This review focuses on metal complex derivatives of PNA. Metal ions and their complexes display unique physical and chemical properties and offer the opportunity to introduce new labels and probes for bioanalytical and diagnostic applications of PNA, but also to modulate or to introduce new (for example catalytic) functions and biological activities.