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Verfasst von:Kumar, Rahul [VerfasserIn]   i
 Ciprianidis, Anja [VerfasserIn]   i
 Theiß, Susanne [VerfasserIn]   i
 Steinbeisser, Herbert [VerfasserIn]   i
 Kaufmann, Lilian [VerfasserIn]   i
Titel:Nemo-like kinase 1 (Nlk1) and paraxial protocadherin (PAPC) cooperatively control Xenopus gastrulation through regulation of Wnt/planar cell polarity (PCP) signaling
Verf.angabe:Rahul Kumar, Anja Ciprianidis, Susanne Theiß, Herbert Steinbeißer, Lilian T. Kaufmann
Jahr:2017
Umfang:12 S.
Fussnoten:Available online 28 October 2016 ; Gesehen am 09.11.2018
Titel Quelle:Enthalten in: Differentiation
Ort Quelle:New York, NY [u.a.] : Elsevier, 1973
Jahr Quelle:2017
Band/Heft Quelle:93(2017), Seite 27-38
ISSN Quelle:1432-0436
Abstract:The Wnt/planar cell polarity (PCP) pathway directs cell migration during vertebrate gastrulation and is essential for proper embryonic development. Paraxial protocadherin (PAPC, Gene Symbol pcdh8.2) is an important activator of Wnt/PCP signaling during Xenopus gastrulation, but how PAPC activity is controlled is incompletely understood. Here we show that Nemo-like kinase 1 (Nlk1), an atypical mitogen-activated protein (MAP) kinase, physically associates with the C-terminus of PAPC. This interaction mutually stabilizes both proteins by inhibiting polyubiquitination. The Nlk1 mediated stabilization of PAPC is essential for Wnt/PCP signaling, tissue separation and gastrulation movements. We identified two conserved putative phosphorylation sites in the PAPC C-terminus that are critical for Nlk1 mediated PAPC stabilization and Wnt/PCP regulation. Intriguingly, the kinase activity of Nlk1 itself was not essential for its cooperation with PAPC, suggesting an indirect regulation for example by impeding a different kinase that promotes protein degradation. Overall these results outline a novel, kinase independent role of Nlk1, wherein Nlk1 regulates PAPC stabilization and thereby controls gastrulation movements and Wnt/PCP signaling during development.
DOI:doi:10.1016/j.diff.2016.10.002
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.diff.2016.10.002
 Volltext: http://www.sciencedirect.com/science/article/pii/S0301468116300743
 DOI: https://doi.org/10.1016/j.diff.2016.10.002
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Gastrulation movements
 Nemo-like kinase
 Paraxial protocadherin
 Ubiquitination
 Wnt/PCP
K10plus-PPN:1582750742
Verknüpfungen:→ Zeitschrift

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