Arterial spin labeling at 3.0 Tesla in subacute ischemia

• Verfasst von: Huck, Sonia [VerfasserIn]
• Verfasst von: Kerl, Hans Ulrich [VerfasserIn]
• Verfasst von: Al-Zghloul, Mansour [VerfasserIn]
• Verfasst von: Groden, Christoph [VerfasserIn]
• Verfasst von: Nölte, Ingo [VerfasserIn]
• Titel: Arterial spin labeling at 3.0 Tesla in subacute ischemia
• Titelzusatz: comparison to dynamic susceptibility perfusion
• Verf.angabe: S. Huck, H.U. Kerl, M. Al-Zghloul, C. Groden, I. Nölte
• E-Jahr: 2012
• Jahr: March 2012
• Umfang: 9 S.
• Fussnoten: Gesehen am 12.11.2018
• Titel Quelle: Enthalten in: Clinical neuroradiology
• Ort Quelle: München : Urban & Vogel, 2006
• Jahr Quelle: 2012
• Band/Heft Quelle: 22(2012), 1, Seite 29-37
• ISSN Quelle: 1869-1447
• ISSN Quelle: 1615-6706
• DOI: doi:10.1007/s00062-011-0126-x
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Arterial spin labeling (ASL)
• Sach-SW: Cerebral perfusion
• Sach-SW: Dynamic susceptibility imaging
• Sach-SW: Magnetic resonance imaging (MRI)
• Sach-SW: Stroke
• Sach-SW: Subacute ischemia
• K10plus-PPN: 1583604278

Abstract

PurposeArterial spin labeling (ASL) is a promising but clinically not established non-invasive method to assess cerebral perfusion. The purpose of this study was to compare perfusion imaging with pulsed ASL (pASL) to conventional dynamic susceptibility contrast (DSC) perfusion-weighted imaging (PWL) using commercially available equipment and postprocessing (3.0 Tesla, 32-channel head coil) in patients with subacute ischemia.MethodsThe pASL and DSC-PWI techniques were compared in 15 patients with subacute ischemia (age 49-88 years, 6 females and 9 males, time from onset to scan 4-161 h). Image inhomogeneity was assessed with the non-uniformity index. Image quality, delineation of hypoperfusion and degree of hypoperfusion were rated by two readers using a 5-scale grading system. The volume of hypoperfusion was quantified planimetrically.ResultsImage quality and image inhomogeneity were superior in DSC time-to-peak (TTP) compared to pASL cerebral brain flow (CBF; both p < 0.05). The delineation of hypoperfusion was better in DSC-TTP (p < 0.05) and the hypoperfusion was graded as more severe in DSC-TTP (p < 0.05). The volume of hypoperfusion did not differ between pASL-CBF and DSC-TTP, however, in pASL-CBF five cases with small infarctions (lacunar and pontine) were false negative compared to DSC-relative CBF. The mismatch frequency was lower in pASL (13%) than in DSC-rCBF (20%) and DSC-TTP (47%).ConclusionsUsing a commercially available sequence and a 32-channel head coil at 3.0 Tesla pASL-CBF is feasible but limited compared to DSC-PWI in the assessment of ischemic stroke. In its present form pASL has a reserve role in clinical practice for situations when gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) is contraindicated.