| Online-Ressource |
Verfasst von: | Huck, Sonia [VerfasserIn]  |
| Kerl, Hans Ulrich [VerfasserIn]  |
| Al-Zghloul, Mansour [VerfasserIn]  |
| Groden, Christoph [VerfasserIn]  |
| Nölte, Ingo [VerfasserIn]  |
Titel: | Arterial spin labeling at 3.0 Tesla in subacute ischemia |
Titelzusatz: | comparison to dynamic susceptibility perfusion |
Verf.angabe: | S. Huck, H.U. Kerl, M. Al-Zghloul, C. Groden, I. Nölte |
E-Jahr: | 2012 |
Jahr: | March 2012 |
Umfang: | 9 S. |
Fussnoten: | Gesehen am 12.11.2018 |
Titel Quelle: | Enthalten in: Clinical neuroradiology |
Ort Quelle: | München : Urban & Vogel, 2006 |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 22(2012), 1, Seite 29-37 |
ISSN Quelle: | 1869-1447 |
| 1615-6706 |
Abstract: | PurposeArterial spin labeling (ASL) is a promising but clinically not established non-invasive method to assess cerebral perfusion. The purpose of this study was to compare perfusion imaging with pulsed ASL (pASL) to conventional dynamic susceptibility contrast (DSC) perfusion-weighted imaging (PWL) using commercially available equipment and postprocessing (3.0 Tesla, 32-channel head coil) in patients with subacute ischemia.MethodsThe pASL and DSC-PWI techniques were compared in 15 patients with subacute ischemia (age 49-88 years, 6 females and 9 males, time from onset to scan 4-161 h). Image inhomogeneity was assessed with the non-uniformity index. Image quality, delineation of hypoperfusion and degree of hypoperfusion were rated by two readers using a 5-scale grading system. The volume of hypoperfusion was quantified planimetrically.ResultsImage quality and image inhomogeneity were superior in DSC time-to-peak (TTP) compared to pASL cerebral brain flow (CBF; both p < 0.05). The delineation of hypoperfusion was better in DSC-TTP (p < 0.05) and the hypoperfusion was graded as more severe in DSC-TTP (p < 0.05). The volume of hypoperfusion did not differ between pASL-CBF and DSC-TTP, however, in pASL-CBF five cases with small infarctions (lacunar and pontine) were false negative compared to DSC-relative CBF. The mismatch frequency was lower in pASL (13%) than in DSC-rCBF (20%) and DSC-TTP (47%).ConclusionsUsing a commercially available sequence and a 32-channel head coil at 3.0 Tesla pASL-CBF is feasible but limited compared to DSC-PWI in the assessment of ischemic stroke. In its present form pASL has a reserve role in clinical practice for situations when gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) is contraindicated. |
DOI: | doi:10.1007/s00062-011-0126-x |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1007/s00062-011-0126-x |
| Volltext: https://doi.org/10.1007/s00062-011-0126-x |
| DOI: https://doi.org/10.1007/s00062-011-0126-x |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Arterial spin labeling (ASL) |
| Cerebral perfusion |
| Dynamic susceptibility imaging |
| Magnetic resonance imaging (MRI) |
| Stroke |
| Subacute ischemia |
K10plus-PPN: | 1583604278 |
Verknüpfungen: | → Zeitschrift |
Arterial spin labeling at 3.0 Tesla in subacute ischemia / Huck, Sonia [VerfasserIn]; March 2012 (Online-Ressource)