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Verfasst von:Huck, Sonia [VerfasserIn]   i
 Kerl, Hans Ulrich [VerfasserIn]   i
 Al-Zghloul, Mansour [VerfasserIn]   i
 Groden, Christoph [VerfasserIn]   i
 Nölte, Ingo [VerfasserIn]   i
Titel:Arterial spin labeling at 3.0 Tesla in subacute ischemia
Titelzusatz:comparison to dynamic susceptibility perfusion
Verf.angabe:S. Huck, H.U. Kerl, M. Al-Zghloul, C. Groden, I. Nölte
E-Jahr:2012
Jahr:March 2012
Umfang:9 S.
Fussnoten:Gesehen am 12.11.2018
Titel Quelle:Enthalten in: Clinical neuroradiology
Ort Quelle:München : Urban & Vogel, 2006
Jahr Quelle:2012
Band/Heft Quelle:22(2012), 1, Seite 29-37
ISSN Quelle:1869-1447
 1615-6706
Abstract:PurposeArterial spin labeling (ASL) is a promising but clinically not established non-invasive method to assess cerebral perfusion. The purpose of this study was to compare perfusion imaging with pulsed ASL (pASL) to conventional dynamic susceptibility contrast (DSC) perfusion-weighted imaging (PWL) using commercially available equipment and postprocessing (3.0 Tesla, 32-channel head coil) in patients with subacute ischemia.MethodsThe pASL and DSC-PWI techniques were compared in 15 patients with subacute ischemia (age 49-88 years, 6 females and 9 males, time from onset to scan 4-161 h). Image inhomogeneity was assessed with the non-uniformity index. Image quality, delineation of hypoperfusion and degree of hypoperfusion were rated by two readers using a 5-scale grading system. The volume of hypoperfusion was quantified planimetrically.ResultsImage quality and image inhomogeneity were superior in DSC time-to-peak (TTP) compared to pASL cerebral brain flow (CBF; both p < 0.05). The delineation of hypoperfusion was better in DSC-TTP (p < 0.05) and the hypoperfusion was graded as more severe in DSC-TTP (p < 0.05). The volume of hypoperfusion did not differ between pASL-CBF and DSC-TTP, however, in pASL-CBF five cases with small infarctions (lacunar and pontine) were false negative compared to DSC-relative CBF. The mismatch frequency was lower in pASL (13%) than in DSC-rCBF (20%) and DSC-TTP (47%).ConclusionsUsing a commercially available sequence and a 32-channel head coil at 3.0 Tesla pASL-CBF is feasible but limited compared to DSC-PWI in the assessment of ischemic stroke. In its present form pASL has a reserve role in clinical practice for situations when gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) is contraindicated.
DOI:doi:10.1007/s00062-011-0126-x
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1007/s00062-011-0126-x
 Volltext: https://doi.org/10.1007/s00062-011-0126-x
 DOI: https://doi.org/10.1007/s00062-011-0126-x
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Arterial spin labeling (ASL)
 Cerebral perfusion
 Dynamic susceptibility imaging
 Magnetic resonance imaging (MRI)
 Stroke
 Subacute ischemia
K10plus-PPN:1583604278
Verknüpfungen:→ Zeitschrift

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