Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Kontogianni, Konstantina [VerfasserIn]   i
 Gompelmann, Daniela [VerfasserIn]   i
 Schuhmann, Maren [VerfasserIn]   i
 Hoffmann, Hans [VerfasserIn]   i
 Heußel, Claus Peter [VerfasserIn]   i
 Herth, Felix [VerfasserIn]   i
 Eberhardt, Ralf [VerfasserIn]   i
Titel:Coil therapy for patients with severe emphysema and bilateral incomplete fissures - effectiveness and complications after 1-year follow-up
Titelzusatz:a single-center experience
Verf.angabe:Konstantina Kontogianni, Vasiliki Gerovasili, Daniela Gompelmann, Maren Schuhmann, Hans Hoffmann, Claus Peter Heussel, Felix JF Herth, Ralf Eberhardt
Jahr:2017
Umfang:12 S.
Fussnoten:Published 23 January 2017 ; Gesehen am 13.11.2018
Titel Quelle:Enthalten in: The International journal of chronic obstructive pulmonary disease
Ort Quelle:Albany, Auckland : DOVE Medical Press, 2006
Jahr Quelle:2017
Band/Heft Quelle:12(2017), Seite 383-394
ISSN Quelle:1178-2005
Abstract:Coil therapy for patients with severe emphysema and bilateral incomplete fissures &ndash; effectiveness and complications after 1-year follow-up: a single-center experience Konstantina Kontogianni,1,2 Vasiliki Gerovasili,3 Daniela Gompelmann,1,2 Maren Schuhmann,1,2 Hans Hoffmann,2,4 Claus Peter Heussel,2,5 Felix JF Herth,1,2 Ralf Eberhardt1,2 1Department of Pulmonology and Respiratory Care Medicine, Thoraxklinik at the University of Heidelberg, 2Translational Lung Research Center Heidelberg, Member of the German Center for Lung Research DZL, Heidelberg, Germany; 3Department of Respiratory Medicine, Harefield Hospital, Royal Brompton & Harefield NHS Foundation Trust, London, UK; 4Department of Thoracic Surgery, Thoraxklinik at the University of Heidelberg, 5Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at the University of Heidelberg, Heidelberg, Germany Background: Lung volume reduction coil (LVRC) treatment is established in daily endoscopic lung volume reduction routine. The aim of this study was to evaluate the safety and efficacy of LVRC treatment.Patients and methods: This was a retrospective analysis of 86 patients (male/female: 40/46, mean age: 64&plusmn;7&nbsp;years) with severe COPD and bilateral incomplete fissures. A total of 10 coils were unilaterally implanted in a single lobe, and 28 out of 86 patients were treated bilaterally. At 90-, 180-, and 365-day follow-up, changes in pulmonary function test (PFT), 6-minute walk test (6MWT) and modified Medical Research Council (mMRC) dyspnea scale, as well as possible complications, were recorded.Results: At 90&nbsp;days, the forced expiratory volume in 1 second did improve (P<0.001), but the improvement was not sustained at the 180- and 365-day follow-up (baseline: 0.71&plusmn;0.21 vs 0.77&plusmn;0.23 vs 0.73&plusmn;0.22 vs 0.70&plusmn;0.18&nbsp;L). Both vital capacity and residual volume improved significantly (P<0.001) at the 90- and 180-day follow-up, but the improvement was lost after 365&nbsp;days. Total lung capacity decreased at the 90-day follow-up but returned to baseline values at the 180- and 365-day follow-up. 6MWT (P=0.01) and mMRC (P=0.007) also improved at 90 and 180&nbsp;days (&Delta;6MWT of 31&plusmn;54 and 20&plusmn;60&nbsp;m, respectively), but the improvement was also lost at the 365-day follow-up. No significant further improvement was evident at any point in the follow-up after the second procedure. A total of 4 out of 86 patients passed away due to complications. Significant complications in the first 3&nbsp;months and then at 12&nbsp;months included the following: severe hemoptysis in 4 (3.5%) and 4 (3.5%) patients, pneumonia requiring hospitalization in 32 (28.1%) and 9 (7.9%) patients and pneumothorax in 7 (6.1%) and 2 (1.7%) patients, respectively. Milder adverse events included self-limited hemoptysis, pneumonias, or COPD exacerbations treated orally.Conclusion: LVRC improved PFT, 6MWT and mMRC initially, but the improvement was lost after 365&nbsp;days. Furthermore, we observed 4 deaths and significant severe complications, which need to be further elucidated.Keywords: COPD, emphysema, bronchoscopy, coils, effectiveness, complications
DOI:doi:10.2147/COPD.S117655
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext ; Verlag: http://dx.doi.org/10.2147/COPD.S117655
 kostenfrei: Volltext: https://www.dovepress.com/coil-therapy-for-patients-with-severe-emphysema-and-bilateral-incomple-peer-reviewed-fulltext- ...
 DOI: https://doi.org/10.2147/COPD.S117655
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1583685685
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68327801   QR-Code
zum Seitenanfang