| |  Online-Ressource |
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| Verfasst von: | Fehr, Eva-Marie [VerfasserIn]  |
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| | Heyder, Petra [VerfasserIn] |
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| | Blank, Norbert [VerfasserIn] |
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| | Lorenz, Hanns-Martin [VerfasserIn] |
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| | Schiller, Martin [VerfasserIn] |
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| Titel: | Apoptotic-cell-derived membrane vesicles induce an alternative maturation of human dendritic cells which is disturbed in SLE |
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| Verf.angabe: | Eva-Marie Fehr, Silvia Spoerl, Petra Heyder, Martin Herrmann, Isabelle Bekeredjian-Ding, Norbert Blank, Hanns-Martin Lorenz, Martin Schiller |
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| Jahr: | 2013 |
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| Umfang: | 10 S. |
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| Fussnoten: | Available online 29 September 2012 ; Gesehen am 14.11.2018 |
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| Titel Quelle: | Enthalten in: Journal of autoimmunity |
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| Ort Quelle: | [Amsterdam] : Elsevier, 1988 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 40(2013), Seite 86-95 |
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| ISSN Quelle: | 1095-9157 |
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| Abstract: | The clearance of apoptotic cells occurs in a non-inflammatory context. Defects in this clearance process have been linked to the emergence of human autoimmune diseases like systemic lupus erythematosus (SLE). A characteristic of apoptotic cell death is the shedding of membrane coated vesicles from the cellular surfaces. Those vesicles have recently been recognized as mediators of intercellular communication or as adjuvant in the pathogenesis of autoimmune diseases. We analyzed the interactions between these apoptotic cell-derived membrane vesicles and professional antigen presenting cells. These vesicles were engulfed by monocyte-derived dendritic cells (mDC) and stimulated their maturation towards a phenotype comprising an upregulation of CD80, CD83, CD86, and a remarkable downregulation of MHC class II molecules. We observed only a minor release of proinflammatory cytokines from these mDC when compared to LPS stimulation. mDC stimulated by apoptotic vesicles did not cause significant T-cell expansion. Interestingly, when compared to normal healthy donors SLE patients-derived dendritic cells showed a significantly different phenotype lacking the downregulation of MHC class II, which correlated to disease activity. |
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| DOI: | doi:10.1016/j.jaut.2012.08.003 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.jaut.2012.08.003 |
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| | DOI: https://doi.org/10.1016/j.jaut.2012.08.003 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Adult |
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| | Aged |
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| | Antigens, CD |
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| | Apoptosis |
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| | B7-1 Antigen |
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| | B7-2 Antigen |
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| | CD4-Positive T-Lymphocytes |
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| | Cell Communication |
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| | Cell Proliferation |
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| | Cells, Cultured |
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| | Cytoplasmic Vesicles |
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| | Dendritic Cells |
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| | Female |
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| | Histocompatibility Antigens Class II |
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| | Humans |
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| | Immunoglobulins |
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| | Interleukin-12 |
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| | Interleukin-8 |
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| | Lupus Erythematosus, Systemic |
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| | Male |
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| | Membrane Glycoproteins |
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| | Middle Aged |
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| | Phagocytosis |
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| | Tumor Necrosis Factor-alpha |
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| | Young Adult |
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| K10plus-PPN: | 1583703942 |
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| Verknüpfungen: | → Zeitschrift |
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Apoptotic-cell-derived membrane vesicles induce an alternative maturation of human dendritic cells which is disturbed in SLE / Fehr, Eva-Marie [VerfasserIn]; 2013 (Online-Ressource)
